BRD8: A Protein Implicated in Disease Development (G10902)

Target Name: BRD8

NCBI ID: G10902

BRD8

BRD8: A Protein Implicated in Disease Development

BRD8 (TrCP120) is a protein that is expressed in various tissues throughout the body, including the brain, spleen, and gastrointestinal tract. It is a member of the superfamily of RNA-binding proteins, known as RNA-protein interactions (RBP) proteins.BRD8 has been shown to play a role in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the unique features of BRD8 is its ability to interact with other proteins through its RBP domain. This domain is known for its ability to form stable interactions with a wide variety of proteins, including transcription factors, translation factors, and cytoplasmic proteins. These interactions can modulate the activity and stability of these proteins, and are a key mechanism by which BRD8 functions.

BRD8 has been shown to play a role in the regulation of cellular processes that are important for the development and progression of cancer. For example, studies have shown thatBRD8 can promote the growth and survival of cancer cells, and can also inhibit the apoptosis (programmed cell death) of cancer cells. This suggests that BRD8 may be a potential drug target for cancer treatment.

BRD8 has also been shown to be involved in the development and progression of neurodegenerative diseases. For example, studies have shown that BRD8 is expressed in the brains of individuals with Alzheimer's disease, and that it is involved in the regulation of neurodegenerate protein synthesis. This suggests that BRD8 may be a potential drug target for neurodegenerative diseases.

BRD8 has also been shown to be involved in the regulation of autoimmune disorders. For example, studies have shown that BRD8 is expressed in the T cells of individuals with rheumatoid arthritis, and that it is involved in the regulation of the immune response. This suggests that BRD8 may be a potential drug target for autoimmune disorders.

In addition to its role in the regulation of cellular processes, BRD8 has also been shown to play a role in the regulation of gene expression. For example, studies have shown that BRD8 can interact with the protein Myb, which is involved in the regulation of DNA binding and gene expression. This suggests that BRD8 may be a potential regulator of gene expression, and that it may be a useful target for small molecules.

Overall, BRD8 is a protein that has been shown to play a role in the development and progression of various diseases. Its ability to interact with other proteins through its RBP domain makes it a potential drug target for a wide variety of conditions. Further research is needed to fully understand the role of BRD8 in these processes, and to determine the most effective way to target it for drug development.

Protein Name: Bromodomain Containing 8

Functions: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome

The "BRD8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BRD8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets