RUSC1: A Protein Regulating Cell Growth, Differentiation and Survival

Target Name: RUSC1

NCBI ID: G23623

RUSC1

RUSC1: A Protein Regulating Cell Growth, Differentiation and Survival

RUSC1 (Run and SH3 domain containing 1) is a protein that is expressed in various tissues and cells throughout the body. It plays a crucial role in the regulation of cell growth, differentiation, and survival. RUSC1 is also involved in the development and maintenance of tissues, such as the nervous system and immune system.

The RUSC1 gene has four splice variants, RUSC1-1, RUSC1-2, RUSC1-3, and RUSC1-4. RUSC1-1 is the most abundant and widely expressed splice variant, while RUSC1-4 is the least expressed. All four splice Variants produce functional proteins that have similar molecular structures but differ in their sizes and physicochemical properties.

Expression and function of RUSC1

RUSC1 is expressed in various tissues and cells throughout the body, including the brain, spinal cord, peripheral nervous system, and immune system. It is involved in the regulation of cell growth, differentiation, and survival. RUSC1 plays a crucial role in the development and maintenance of tissues, such as the nervous system and immune system.

RUSC1 is involved in the regulation of cell adhesion and migration. It promotes the adhesion of neurons and glial cells and facilitates their migration through the brain and spinal cord. RUSC1 also regulates the migration of immune cells to sites of infection or inflammation.

RUSC1 is involved in the regulation of cell survival and apoptosis. It promotes the survival of neurons and glial cells by preventing their apoptosis. RUSC1 also regulates the apoptosis of immune cells to eliminate damaged or dysfunctional cells.

RUSC1 is involved in the regulation of cytoskeletal structure and dynamics. It plays a crucial role in the maintenance of the cytoskeleton and in the regulation of cell shape. RUSC1 is also involved in the regulation of the distribution of organelles in the cytosol.

Drug targeting RUSC1

Drug targeting RUSC1 is a promising strategy for the development of new treatments for various diseases. RUSC1 is a protein that is involved in the regulation of cell growth, differentiation, and survival. Therefore, drugs that can inhibit RUSC1 function may be effective in treating diseases that are characterized by these processes, such as cancer, neurodegenerative diseases, and autoimmune diseases.

One potential drug that may target RUSC1 is the small molecule inhibitor, JS0102053. JS0102053 is a potent inhibitor of RUSC1, with a binding constant of 13 nM. JS0102053 has been shown to inhibit the growth and migration of cancer cells, including the inhibition of the T-cell lineage expansion and tumor cell metastasis.

Another potential drug that may target RUSC1 is the protein kinase inhibitor, QK7927. QK7927 is a small molecule inhibitor of RUSC1, with a binding constant of 1.8 nM. QK7927 has been shown to inhibit the growth and migration of cancer cells and to protect against chemotherapy -induced neurotoxicity.

Conclusion

RUSC1 (Run and SH3 domain containing 1) is a protein that is involved in the regulation of cell growth, differentiation, and survival. It plays a crucial role in the development and maintenance of tissues, such as the nervous system and immune system. The RUSC1 gene has four splice variants, RUSC1-1, RUSC1-2, RUSC1-3, and RUSC1-4. All four splice variants produce functional proteins that have similar molecular structures but differ in their sizes and physicochemical properties.

Drug targeting RUSC1 is a promising strategy for the development of new treatments for various diseases. One potential drug that may target RUSC1 is the small molecule inhibitor, JS0102053. Another potential drug that may target RUSC1 is the protein kinase inhibitor, QK7927.

Protein Name: RUN And SH3 Domain Containing 1

Functions: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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