Target Name: ZNF764
NCBI ID: G92595
Review Report on ZNF764 Target / Biomarker Content of Review Report on ZNF764 Target / Biomarker
ZNF764
Other Name(s): Zinc finger protein 764, transcript variant 1 | Zinc finger protein 764 (isoform 1) | zinc finger protein 764 | ZNF764 variant 1 | Zinc finger protein 764, transcript variant 2 | ZN764_HUMAN | ZNF764 variant 2 | Zinc finger protein 764 (isoform 2) | Zinc finger protein 764

ZNF764: A Potential Drug Target and Biomarker for Inflammatory Neurodegenerative Diseases

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes, including gene regulation, DNA replication, and cell signaling. ZNF764, also known as Zinc finger protein 764, is a member of the ZNF family and has been identified as a potential drug target and biomarker for inflammatory neurodegenerative diseases.

In this article, we will provide an overview of ZNF764, including its structure, function, and potential therapeutic applications. We will discuss the underlying molecular mechanisms that contribute to its potential as a drug target and biomarker, as well as current research efforts to investigate its clinical potential.

Structure and Function

ZNF764 is a 21-kDa protein that consists of a unique N-terminal zinc finger domain and a variable-length C-terminal transmembrane region. The N-terminal zinc finger domain is a well- conserved region that contains a zinc finger core and a variable N-terminal hypervariable region (HVR). The C-terminal region of ZNF764 is responsible for its unique 21-kDa size and is characterized by a series of conserved transmembrane domains, including a carboxy-terminal domain, a single transmembrane domain, and a variable C-terminal hypervariable region (HVR).

ZNF764 functions as a transcription factor that regulates gene expression. It has been shown to play a role in various cellular processes, including cell growth, differentiation, and inflammation. ZNF764 has been shown to promote the expression of target genes that are involved in cell signaling pathways, such as the TGF-β pathway, the NF-kappa-B pathway, and the AP-1/TAZ signaling pathway.

In addition to its role in gene regulation, ZNF764 has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to regulate the activity of several intracellular signaling pathways, including the TGF-β pathway, the NF-kappa-B pathway, and the PI3K/AKT signaling pathway. ZNF764 has also been shown to play a role in the regulation of cellular adhesion, as it has been shown to interact with several adhesion molecules, including cadherins and immunoglobulin E (IgE).

Potential Therapeutic Applications

The potential therapeutic applications of ZNF764 are vast and varied. As a drug target, ZNF764 has the potential to treat a variety of inflammatory neurodegenerative diseases, including multiple sclerosis, rheumatoid arthritis, and neuroinflammatory diseases.

One of the potential therapeutic applications of ZNF764 is its ability to modulate the activity of intracellular signaling pathways that are involved in the development and progression of inflammatory neurodegenerative diseases. For example, ZNF764 has been shown to regulate the activity of the TGF-β pathway, a pathway that is involved in the development of neurodegeneration in various diseases, including multiple sclerosis and Alzheimer's disease. By modulating the activity of the TGF-β pathway, ZNF764 has the potential to treat these diseases and improve patient outcomes.

ZNF764 has also been shown to have potential therapeutic applications in the treatment of pain. It has been shown to regulate the activity of intracellular signaling pathways that are involved in the sensation of pain, including the TGF-β pathway. By modulating the activity of the TGF-β pathway, ZNF764 has the potential to treat

Protein Name: Zinc Finger Protein 764

Functions: Zinc finger protein that functions as a cofactor for steroid hormone receptors, such as NR3C1/GR (PubMed:28139699). Directs NR3C1/GR transcriptional activity toward specific biologic pathways by changing NR3C1/GR binding and transcriptional activity on the glucocorticoid-responsive genes (PubMed:28139699)

The "ZNF764 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF764 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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