Target Name: ZNF789
NCBI ID: G285989
Review Report on ZNF789 Target / Biomarker Content of Review Report on ZNF789 Target / Biomarker
ZNF789
Other Name(s): Zinc finger protein 789 (isoform 1) | Zinc finger protein 789, transcript variant 1 | ZN789_HUMAN | Zinc finger protein 789 | ZNF789 variant 1 | OTTHUMP00000214545 | OTTHUMP00000206245 | zinc finger protein 789

ZNF789: A Potential Drug Target and Biomarker

Introduction

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF789 (also known as Zinc finger protein 789 or ISOform 1) is a ZNF protein that is expressed in various tissues and cells, including neural elements, endothelial cells, and various types of cancer cells. Its unique structure and function make it an attractive drug target and a potential biomarker for various diseases.

Structure and Function

ZNF789 is a 21-kDa protein that consists of a single ZNF domain and a single N-terminal ZNF2-like domain. The ZNF domain is responsible for the protein's unique structure and function. It contains a short N-terminal alpha helix, a long alpha-helices region, and a C-terminal ZNF2-like domain. The ZNF2-like domain is a conserved region that is similar to ZNF2, another key protein in the ZNF family.

The ZNF789 protein is involved in various cellular processes, including cell signaling, cell growth, and apoptosis. One of its most significant functions is that of a negative regulator of the transforming growth factor beta (TGF-β). TGF-β is a vital factor that regulates cell growth, differentiation, and survival, and its activity is often disrupted in various diseases, including cancer. Therefore, targeting ZNF789 as a drug target could provide new insights into the mechanisms of these diseases and could potentially lead to new treatments.

Expression and Localization

ZNF789 is expressed in various tissues and cells, including the brain, spinal cord, heart, and cancer cells. Its expression is often highest in neural cells, indicating that it plays an important role in the development and maintenance of neural tissue. ZNF789 is also expressed in endothelial cells, which are responsible for maintaining blood vessel integrity and have a key role in various diseases, including cardiovascular disease.

ZNF789 is also expressed in various types of cancer cells, making it an attractive drug target for cancer therapies. Cancer is a leading cause of death worldwide, and there is a growing interest in finding new treatments that can effectively target this disease. By targeting ZNF789 , researchers could potentially develop new therapies that specifically target cancer cells and have a reduced impact on healthy cells.

Drug Interactions

ZNF789 is a protein that is involved in various cellular processes, making it an attractive drug target for small molecules. Researchers have developed a number of compounds that can interact with ZNF789 and have used these compounds to investigate its function. One of the most promising compounds is a small molecule called a novel compound, which has been shown to interact with ZNF789 and inhibit its activity.

Conclusion

ZNF789 is a unique protein that is involved in various cellular processes and has been shown to play a role in various diseases, including cancer. Its structure and function make it an attractive drug target for small molecules, and its expression in various tissues and cells makes it a potential biomarker for these diseases. Further research is needed to fully understand the role of ZNF789 in these diseases and to develop new treatments that can effectively target it.

Protein Name: Zinc Finger Protein 789

Functions: May be involved in transcriptional regulation

The "ZNF789 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF789 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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