ZNF84: A Potential Drug Target and Biomarker (G7637)

Target Name: ZNF84

NCBI ID: G7637

ZNF84

ZNF84: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. ZNF84, a member of the ZNF family, is a protein that has been identified as a potential drug target and biomarker. In this article, we will discuss the biology of ZNF84, its potential drug targets, and its potential as a biomarker for various diseases.

Biography of ZNF84

ZNF84 is a 21-kDa protein that is expressed in various tissues, including brain, heart, liver, and pancreas. It is a key component of the ZNF8 complex, which is responsible for regulating gene expression and cell signaling. ZNF84 is composed of a unique nucleotide-binding domain, a transmembrane region, and a cytoplasmic tail.

Function of ZNF84

The function of ZNF84 is to regulate gene expression and cell signaling by interacting with various transcription factors. It plays a crucial role in the regulation of stem cell proliferation, differentiation, and survival. ZNF84 has been shown to promote the self-renewal and plasticity of neural stem cells, and it has been linked to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia.

Potential Drug Targets

ZNF84 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. Several studies have shown that ZNF84 can be targeted by small molecules, including inhibitors of its nucleotide-binding domain and transmembrane region. These inhibitors have been shown to enhance the inhibition of neuronal differentiation and promote the differentiation of neural stem cells.

In addition to its potential as a drug target, ZNF84 has also been identified as a potential biomarker for various diseases. The ZNF8 complex has been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and apoptosis. Therefore, changes in the expression level of ZNF84 may be an indicator of certain diseases, such as cancer, neurodegenerative diseases, and neurological disorders.

Potential Applications

The potential applications of ZNF84 as a drug target and biomarker are vast. The development of small molecules that can inhibit ZNF84 activity could lead to new treatments for various diseases. For example, inhibitors of ZNF84's nucleotide-binding domain have been shown to be effective in treating neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.

In addition to its potential as a drug, ZNF84 has also been identified as a potential biomarker for various diseases. The ZNF8 complex has been shown to be involved in the regulation of various cellular processes, including cell signaling, DNA replication, and apoptosis. Therefore, changes in the expression level of ZNF84 may be an indicator of certain diseases, such as cancer, neurodegenerative diseases, and neurological disorders.

Conclusion

In conclusion, ZNF84 is a protein that has the potential to be a drug target and biomarker for various diseases. Its unique structure and its involvement in various cellular processes make it an attractive target for small molecules. Further research is needed to fully understand the biology of ZNF84 and its potential as a drug and biomarker.

Protein Name: Zinc Finger Protein 84

Functions: May be involved in transcriptional regulation

The "ZNF84 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF84 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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