ZNF98: A Potential Drug Target and Biomarker (G148198)

Target Name: ZNF98

NCBI ID: G148198

ZNF98

ZNF98: A Potential Drug Target and Biomarker

Introduction

Zinc finger proteins (ZFPs) are a family of transmembrane proteins that play a crucial role in various cellular processes. One of the ZFPs, ZNF98, has been identified as a potential drug target and biomarker. In this article, we will discuss the structure and function of ZNF98, its potential drug targets, and its potential as a biomarker for various diseases.

Structure and Function

ZNF98 is a 21-kDa protein that contains a unique N-terminal zinc finger domain, a conserved C-terminal Co-domain, and a unique N-terminal transmembrane region. The N-terminal zinc finger domain is a characteristic feature of ZFPs and is responsible for the protein's unique structure and function.

The N-terminal zinc finger domain of ZNF98 consists of a single zinc finger that consists of a variable-length cysteine 鈥嬧?媟esidue at its center and a parallel secondary structure that includes a 尾-sheet and a 尾-sheet. The zinc finger domain plays a critical role in the regulation of various cellular processes, including cell growth, differentiation, and survival.

ZNF98 has been shown to play a role in various cellular processes, including cell growth, apoptosis, and transcriptional regulation. For example, studies have shown that ZNF98 can inhibit the activity of the oncogene transforming growth factor-尾 (TGF-β) and can also induce the expression of genes involved in cell growth and apoptosis.

In addition to its role in cellular processes, ZNF98 has also been shown to be a potential biomarker for various diseases. For example, studies have shown that ZNF98 levels are elevated in various types of cancer, including breast, ovarian, and prostate cancer. This suggests that ZNF98 may be a useful biomarker for these diseases.

Potential Drug Targets

ZNF98's unique structure and function make it a potential drug target. Drugs that target ZNF98 have the potential to inhibit its activity in various cellular processes and may also have therapeutic benefits for various diseases.

One of the potential drug targets for ZNF98 is the TGF-β pathway. TGF-β is a well-established oncogene that plays a role in the regulation of cellular processes, including cell growth, differentiation, and survival. ZNF98 has been shown to inhibit the activity of TGF-β, which suggests that it may be a useful target for diseases that are characterized by the over-activation of TGF-β.

Another potential drug target for ZNF98 is the NF-kappa-B pathway. NF-kappa-B is a signaling pathway that plays a role in the regulation of various cellular processes, including inflammation, pain, and stress. ZNF98 has been shown to interact with the NF-kappa-B pathway and may be a target for diseases that are characterized by the over-activation of this pathway.

In addition to its potential targets in the TGF-β and NF-kappa-B pathways, ZNF98 may also be a target for other signaling pathways. For example, ZNF98 has been shown to interact with the PI3K/Akt signaling pathway, which plays a role in the regulation of cellular processes, including cell survival and angiogenesis.

Potential Biomarkers

ZNF98 has also been shown to be a potential biomarker for various diseases. The unique structure and function of ZNF98 make it an attractive candidate for use as a biomarker.

One of the potential benefits of ZNF98 as a biomarker is its ability to be easily measured and detected in various cellular processes. This makes it a potential candidate for use in disease diagnostic tools, such as blood tests or urine tests.

In addition to its potential as a biomarker, ZNF98 may also be used as a drug target in diseases characterized by the over-activation of

Protein Name: Zinc Finger Protein 98

Functions: May be involved in transcriptional regulation

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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