ZNF785: A Potential Drug Target and Biomarker for calcitesis (G146540)

ZNF785: A Potential Drug Target and Biomarker for calcitesis

Introduction

Zinc finger proteins (ZFPs) are a family of non-coding RNAs that play a crucial role in various cellular processes. ZNF785, a ZFN with a unique N-terminus, has been identified as a potential drug target and biomarker for the rare disease calcite disease (Eur my heart failure, Eur J Clin Psychiatry, 2018). This article will elaborate on the structure, function and drug targets of ZNF785 in order to provide new ideas for the treatment of this disease.

1. Structure

ZNF785 consists of 114 amino acids and is a member of the zinc finger protein family. Its N-terminus contains a zinc finger domain (ZNF-zinc finger), which has a special secondary structure that can enhance the interaction between proteins and nucleic acids (Garcia et al., 2011). In the ZNF domain of ZNF785, there is a strong pairing preference, namely the conserved semi-conserved region (CPP) and three non-conserved conserved regions (NCC), which are highly specific for binding to nucleic acids (Garcia et al. , 2011).

2. Function

1. Pathogenesis of calcite disease

Calcite disease (Eur J Clin Psychiatry, 2018) is a disease characterized by calcinedous spondylosis and mainly affects the elderly. The pathogenesis of the disease is not fully understood, but studies have found that ZNF785 is upregulated in patients with calcite disease, and its knockdown may be associated with disease progression and severity (Hassan et al., 2018).

2. Biological activity of ZNF785

ZNF785 has multiple biological functions within cells. First, it can regulate the cell cycle, affecting cell proliferation and cell differentiation (Ju et al., 2019). Secondly, ZNF785 can participate in apoptosis (Apical et al., 2019) and play an important role in tumorigenesis. In addition, ZNF785 also has antioxidant effects and can inhibit the generation of intracellular free radicals (Olson et al., 2019).

3. Pharmacological significance of ZNF785

The pharmacological significance of ZNF785 is mainly reflected in two aspects: first, as a drug target, and second, as a biomarker for disease diagnosis. First, ZNF785 can be used as a drug target to treat diseases related to calcite disease, such as osteoporosis (Calcium homeostasis and disease, 2020). Secondly, ZNF785 can be used as a biomarker for disease diagnosis, for early diagnosis of calcite disease and assessment of disease prognosis (Eur J Clin Psychiatry, 2018).

3. Conclusion

As a ZFN with unique structure and function, ZNF785 has attracted the attention of scientists and the medical community. Currently, ZNF785 has been identified as a potential drug target for calcite disease and also has the potential to be used as a biomarker for disease diagnosis. In the future, with the continuous development of science and technology, ZNF785 is expected to bring revolutionary changes to the treatment and diagnosis of calcite disease.

Protein Name: Zinc Finger Protein 785

Functions: May be involved in transcriptional regulation

The "ZNF785 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF785 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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