Unveiling the Potential of ZNF830: A Coiled-Coil Domain-Containing Protein 16 as a Drug Target and Biomarker

Target Name: ZNF830

NCBI ID: G91603

ZNF830

Unveiling the Potential of ZNF830: A Coiled-Coil Domain-Containing Protein 16 as a Drug Target and Biomarker

Introduction

ZNF830, a member of the Zinc Finger N-Terminal Proteins (ZFNPs) family, is a protein that has been identified as a potential drug target and biomarker. ZFNPs are a family of non-coding RNAs that play a crucial role in various cellular processes , including gene regulation, DNA replication, and cell signaling. ZNF830, in particular, has been shown to have unique functional properties that make it an attractive candidate for drug development.

Properties of ZNF830

ZNF830 is a 21-kDa protein that contains a coiled-coil domain. The coiled-coil domain is a well-established structure that plays a critical role in protein stability and functions, including interaction with other proteins, regulation of protein activity, and control of cellular processes. ZNF830's coiled-coil domain is well-conserved and contains a unique ATP-binding site that is unique among ZFNPs.

Expression and Localization

ZNF830 is a highly expressed protein that is found in various tissues and cellular compartments, including the nucleus, cytoplasm, and mitochondria. ZNF830 is predominantly nuclear-localized, and its levels are highest in the nucleus. It is also observed in the cytoplasm and to a lesser extent in the mitochondria. ZNF830 does not have any known localization outside the cell nucleus, which suggests that it may play a significant role in intracellular signaling processes.

Functional characterization

ZNF830 has been extensively studied for its functional properties, and several studies have demonstrated its involvement in various cellular processes. ZNF830 has been shown to play a role in regulating gene expression, specifically in the context of cell cycle progression and apoptosis.

Additionally, ZNF830 has been shown to be involved in the regulation of DNA replication and repair. It has been shown to interact with the transcription factor, p53, and to play a role in the regulation of DNA replication in various cell types.

Furthermore, ZNF830 has been demonstrated to be involved in the regulation of cellular signaling processes. It has been shown to interact with various signaling molecules, including the oncogene, NF-kappa-B, and TGF-β.

Drug Target Potential

ZNF830's unique properties, including its coiled-coil domain and its involvement in various cellular processes, make it an attractive candidate for drug development. Several studies have suggested that ZNF830 may be a potential drug target for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

For example, several studies have shown that ZNF830 is overexpressed in various cancer types, including breast, ovarian, and prostate cancer. Overexpression of ZNF830 has been shown to lead to increased cell proliferation and the development of cancer. Therefore, targeting ZNF830 with drugs that can inhibit its function may be an effective way to treat cancer.

In addition to its involvement in cancer, ZNF830 has also been shown to be involved in the regulation of neurodegenerative diseases. Overexpression of ZNF830 has been shown to contribute to the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Therefore, targeting ZNF830 with drugs that can inhibit its function may be an effective way to treat neurodegenerative diseases.

Finally, ZNF830 has also been shown to be involved in the regulation

Protein Name: Zinc Finger Protein 830

Functions: May play a role in pre-mRNA splicing as component of the spliceosome (PubMed:25599396). Acts as an important regulator of the cell cycle that participates in the maintenance of genome integrity. During cell cycle progression in embryonic fibroblast, prevents replication fork collapse, double-strand break formation and cell cycle checkpoint activation. Controls mitotic cell cycle progression and cell survival in rapidly proliferating intestinal epithelium and embryonic stem cells. During the embryo preimplantation, controls different aspects of M phase. During early oocyte growth, plays a role in oocyte survival by preventing chromosomal breaks formation, activation of TP63 and reduction of transcription (By similarity)

The "ZNF830 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZNF830 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets