Target Name: CD19
NCBI ID: G930
Review Report on CD19 Target / Biomarker Content of Review Report on CD19 Target / Biomarker
CD19
Other Name(s): CD19 molecule, transcript variant 2 | B4 | CD19 molecule | B-lymphocyte antigen CD19 | T-cell surface antigen Leu-12 | CD19 molecule, transcript variant 1 | CD19 variant 1 | B-lymphocyte antigen CD19 (isoform 1) | B-lymphocyte surface antigen B4 | CD19_HUMAN | CVID3 | B-lymphocyte antigen CD19 (isoform 2) | CD19 variant 2 | Differentiation antigen CD19 | differentiation antigen CD19

CD19: A Potential Drug Target and Biomarker

CD19 is a molecule that has garnered significant attention in recent years due to its potential as a drug target and biomarker. CD19 is a type of protein that is expressed in various tissues and cell types in the human body. It is a member of the B-cell receptor (BCR) family and is involved in the regulation of immune responses, as well as cell signaling and adhesion.

CD19 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. One of the key reasons for its potential as a drug target is its expressed status in a variety of tissues, including blood, bone marrow, and various organs. Additionally, CD19 has been shown to play a role in the regulation of cellular processes that are important for the development and progression of various diseases, such as cancer, autoimmune disorders, and neurodegenerative diseases.

CD19 is also a potential biomarker due to its ability to be targeted with small molecules. This is because its structure allows for the development of small molecules that can interact specifically with CD19 and modulate its function. This is a promising approach for the development of new treatments for a variety of diseases.

CD19's Role in Immune Response

CD19 is involved in the regulation of the immune response, specifically in the regulation of T cells. T cells are a crucial part of the immune system and play a key role in the regulation of cellular processes that are important for the development and progression of various diseases. CD19 is shown to regulate the proliferation and differentiation of T cells, as well as the regulation of their interactions with other immune cells.

CD19's Role in Cancer

CD19 has also been shown to play a role in the regulation of the immune response in the context of cancer. cancer is a disease that can be caused by the uncontrolled proliferation of cells, and the immune system is a critical component of the fight against cancer. CD19 is shown to regulate the activity of T cells in the context of cancer, and it has been shown to play a role in the development and progression of various types of cancer.

CD19's Role in Autoimmune Disorders

CD19 is also involved in the regulation of the immune response in the context of autoimmune disorders. autoimmune disorders are a group of diseases that occur when the immune system attacks the body's own tissues and can cause a range of symptoms, including pain, fatigue, and inflammation. CD19 is shown to play a role in the regulation of the immune response in the context of autoimmune disorders, and it has been shown to contribute to the development and progression of these disorders.

CD19's Role in Neurodegenerative Diseases

CD19 is also involved in the regulation of the immune response in the context of neurodegenerative diseases. neurodegenerative diseases are a group of diseases that are characterized by the progressive loss of brain cells and can cause a range of symptoms, including cognitive decline, weakness, and behavioral changes. CD19 is shown to play a role in the regulation of the immune response in the context of neurodegenerative diseases, and it has been shown to contribute to the development and progression of these disorders.

CD19 as a Drug Target

CD19's unique structure and its involvement in various cellular processes make it an attractive target for small molecule inhibitors. studies have shown that inhibiting CD19 can lead to the inhibition of various cellular processes that are important for the development and progression of various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

One of the key challenges in the development of CD19 inhibitors is the identification of small molecules that can specifically inhibit

Protein Name: CD19 Molecule

Functions: Functions as coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes. Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:2463100, PubMed:1373518, PubMed:16672701). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:9382888, PubMed:9317126, PubMed:12387743, PubMed:16672701). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:2463100, PubMed:1373518). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:9317126, PubMed:12387743, PubMed:16672701)

The "CD19 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CD19 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

CD1A | CD1B | CD1C | CD1D | CD1E | CD2 | CD200 | CD200R1 | CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A