CD47's Role in Disease Development and Treatment (G961)
CD47's Role in Disease Development and Treatment
CD47 is a protein that is expressed in various cell types, including blood cells, epithelial cells, and myeloid cells. It is a member of the tyrosine kinase family and is involved in the development and maintenance of hematopoietic stem cells, as well as their pro-inflammatory and pro-mutational states.
CD47 has also been implicated in the regulation of cancer progression and the treatment of various diseases, including cancer, sepsis, and chronic obstructive pulmonary disease (COPD). Its role in these processes has led to its potential as a drug target or biomarker.
CD47 is a protein that is expressed in various cell types, including blood cells, epithelial cells, and myeloid cells. It is a member of the tyrosine kinase family and is involved in the development and maintenance of hematopoietic stem cells, as well as their pro-inflammatory and pro-mutational states.
CD47 has been shown to play a role in the development and progression of various diseases, including cancer. For example, studies have shown that high levels of CD47 are associated with poor prognosis in patients with acute myeloid leukemia and other hematological cancers. Additionally, CD47 has been shown to be a potential drug target for cancer, with several inhibitors currently in clinical trials.
In addition to its role in cancer, CD47 has also been implicated in the regulation of sepsis, a life-threatening condition that occurs when the body's response to an infection becomes uncontrolled and causes widespread inflammation. Studies have shown that CD47 plays a role in the regulation of sepsis by regulating the production of pro-inflammatory cytokines.
CD47 has also been shown to be involved in the regulation of chronic obstructive pulmonary disease (COPD), a progressive lung disease that affects millions of people worldwide. Studies have shown that CD47 plays a role in the regulation of COPD by regulating the production of pro-inflammatory cytokines and by contributing to the fibrosis of the lungs.
In conclusion, CD47 is a protein that has been shown to play a role in the development and progression of various diseases, including cancer, sepsis, and COPD. Its potential as a drug target or biomarker makes it an attractive target for research and development of new treatments for these diseases.
Protein Name: CD47 Molecule
Functions: Adhesive protein that mediates cell-to-cell interactions (PubMed:11509594, PubMed:15383453). Acts as receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (PubMed:19004835, PubMed:8550562, PubMed:7691831). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:27742621, PubMed:19004835, PubMed:8550562, PubMed:11509594, PubMed:7691831, PubMed:32679764, PubMed:15383453). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (By similarity). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (PubMed:11509594). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (PubMed:15383453). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (By similarity). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (By similarity). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (By similarity). May play a role in membrane transport and/or integrin dependent signal transduction (PubMed:7691831). May prevent premature elimination of red blood cells (By similarity)
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• general information;
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• expression level;
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More Common Targets
CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7 | CDC73 | CDCA2 | CDCA3 | CDCA4 | CDCA4P3 | CDCA5 | CDCA7 | CDCA7L | CDCA8 | CDCP1 | CDCP2 | CDH1 | CDH10 | CDH11 | CDH12 | CDH13 | CDH13-AS2 | CDH15 | CDH16 | CDH17 | CDH18 | CDH19 | CDH2 | CDH20 | CDH22
