Target Name: CD200R1
NCBI ID: G131450
Review Report on CD200R1 Target / Biomarker Content of Review Report on CD200R1 Target / Biomarker
CD200R1
Other Name(s): cell surface glycoprotein OX2 receptor 1 | CD200 receptor 1, transcript variant 1 | MOX2 receptor | MOX2R | Cell surface glycoprotein receptor CD200 | Cell surface glycoprotein OX2 receptor 1 | CD200R1 variant 1 | Cell surface glycoprotein CD200 receptor 1 | Cell surface glycoprotein CD200 receptor 1 (isoform a) | HCRTR2 | CD200 receptor 1, transcript variant 2 | CD200R | MO2R1_HUMAN | Cell surface glycoprotein CD200 receptor 1 (isoform d) | Cell surface glycoprotein CD200 receptor 1 (isoform b) | CD200 | CD200 receptor 1 | cell surface glycoprotein receptor CD200 | Cell surface glycoprotein OX2 receptor | OX2R | CD200R1 variant 2 | CD200R1 variant 4 | CD200 cell surface glycoprotein receptor | CD200 receptor 1, transcript variant 4

CD200R1: A Promising Drug Target and Biomarker for Chronic Pain Management

Chronic pain is a significant public health issue, affecting millions of people worldwide. The persistent nature of pain can have a significant impact on an individual's quality of life, leading to functional limitations, disability, and even depression. As CD200R1, a cell surface glycoprotein known as OX2 receptor 1, has been identified as a potential drug target and biomarker for chronic pain management. In this article, we will explore the role of CD200R1 in pain modulation and its potential as a drug target.

CD200R1: A Glycoprotein for Pain Modulation

CD200R1 is a cell surface glycoprotein that consists of two constant (C1) and two variable (C2) subunits. It is expressed in various tissues, including peripheral blood mononuclear cells (PBMCs), brain endothelial cells, and glial cells in the central nervous system (CNS). CD200R1 has been shown to play a critical role in pain modulation, with several studies suggesting that it may serve as a potential drug target for chronic pain relief.

CD200R1's role in pain modulation is multifaceted and complex. Firstly, CD200R1 has been shown to regulate pain transmission, as demonstrated in experiments using animal models of pain. For instance, CD200R1 has been shown to inhibit the neuropeptide S100AJ-induced pain hypersensitivity in rats. Additionally, CD200R1 has been shown to modulate pain perception in humans, with studies indicating that it may play a role in the modulation of pain sensitivity to thermal and chemical stimuli.

Secondly, CD200R1 may serve as a biomarker for tracking the efficacy of pain medications. The efficacy of pain medications can be difficult to determine, as their effects can vary from patient to patient and may be influenced by various factors, such as the underlying cause of the pain, the severity of the pain, and the individual's response to the medication. CD200R1 has been shown to be a potential biomarker for tracking the efficacy of pain medications, as it has been shown to be downregulated in individuals with chronic pain. For instance, a study by Nimmerjahn et al. (2018) found that individuals with chronic low back pain had decreased expression of CD200R1 in their peripheral blood mononuclear cells, which may have implications for the efficacy of pain medications.

CD200R1 as a Drug Target

CD200R1's potential as a drug target is an exciting area of research, with several studies suggesting that it may be a valuable target for the treatment of chronic pain. One potential mechanism by which CD200R1 may be targeted is its role in modulating pain signaling.

CD200R1 has been shown to play a role in the regulation of pain signaling by neuropeptides. For instance, a study by Zhang et al. (2018) found that CD200R1 was involved in the regulation of pain sensitivity to oxytocin, a neurotransmitter that is involved in pain signaling. Additionally, a study by Wang et al. (2018) found that CD200R1 was involved in the regulation of pain signaling by endogenous opioids, such as endorphins and opiates.

Another potential mechanism by which CD200R1 may be targeted is its role in modulating pain perception. CD200R1 has been shown to play a role in the regulation of pain perception by GPR117, a receptor that is involved in pain perception. For instance, a study by Zheng et al. (2018) found that CD200R1 was involved in the regulation of pain perception in humans, with decreased expression of CD200R1 in individuals with higher pain pain thresholds.

CD200R1 has also been shown to play a role in modulating pain modulation by the immune system. For instance, a study by Liu et al. (2018) found that CD200R1 was involved in the regulation of pain modulation by the immune system, with increased expression of CD200R1 in individuals with chronic pain.

Conclusion

CD200R1 is a cell surface glycoprotein that has been shown to play a critical role in pain modulation. Its potential as a drug target for chronic pain management is an exciting area of research, with several studies suggesting that it may be a valuable target for the development of new pain medications. Further research is needed to fully understand the role of CD200R1 in pain modulation and its potential as a drug target.

Protein Name: CD200 Receptor 1

Functions: Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200

The "CD200R1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CD200R1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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CD200R1L | CD207 | CD209 | CD22 | CD226 | CD24 | CD244 | CD247 | CD248 | CD24P2 | CD27 | CD27-AS1 | CD274 | CD276 | CD28 | CD2AP | CD2BP2 | CD3 Complex (T Cell Receptor Complex) | CD300A | CD300C | CD300E | CD300LB | CD300LD | CD300LD-AS1 | CD300LF | CD300LG | CD302 | CD320 | CD33 | CD34 | CD36 | CD37 | CD38 | CD3D | CD3E | CD3G | CD4 | CD40 | CD40LG | CD44 | CD44-DT | CD46 | CD47 | CD48 | CD5 | CD52 | CD53 | CD55 | CD58 | CD59 | CD5L | CD6 | CD63 | CD68 | CD69 | CD7 | CD70 | CD72 | CD74 | CD79A | CD79B | CD8 | CD80 | CD81 | CD81-AS1 | CD82 | CD83 | CD84 | CD86 | CD8A | CD8B | CD8B2 | CD9 | CD93 | CD96 | CD99 | CD99L2 | CD99P1 | CDA | CDADC1 | CDAN1 | CDC123 | CDC14A | CDC14B | CDC14C | CDC16 | CDC20 | CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1