Target Name: CD3D
NCBI ID: G915
Review Report on CD3D Target / Biomarker Content of Review Report on CD3D Target / Biomarker
CD3D
Other Name(s): CD3 delta subunit of T-cell receptor complex | CD3D variant 2 | T-cell surface glycoprotein CD3 delta chain (isoform B) | CD3 delta subunit of T-cell receptor complex, transcript variant 1 | CD3 delta subunit of T-cell receptor complex, transcript variant 2 | CD3D variant 1 | CD3DELTA | IMD19 | CD3d antigen | CD3-DELTA | CD3d | OKT3, delta chain | CD3d molecule, delta (CD3-TCR complex) | CD3D_HUMAN | CD3d antigen, delta polypeptide (TiT3 complex) | CD3 antigen, delta subunit | T-cell surface glycoprotein CD3 delta chain (isoform A) | T-cell receptor T3 delta chain | CD3 delta | T-cell surface glycoprotein CD3 delta chain | T3D | T-cell surface glycoprotein CD3 delta chain [Precursor]

CD3D as a Potential Drug Target or Biomarker for T-cell Receptor Complex

Introduction

CD3D (CD3 delta subunit of T-cell receptor complex) is a protein that plays a crucial role in the regulation of T-cell receptor (TCR) signaling. CD3D is a 22-kDa glycoprotein that consists of two constant (C1) and two variable (C2) regions. It is located at the intracellular portion of the T-cell receptor complex, which is responsible for T-cell activation and proliferation. CD3D has been identified as a potential drug target or biomarker due to its unique structure, function , and potential clinical applications.

Structure and Function

CD3D is a glycoprotein that consists of two heavy chains (H1 and H2) and two light chains (L1 and L2). The H1 and H2 chains contain the variable regions, while the L1 and L2 chains contain the constant regions. The variable regions contain the extracellular portion of the protein, which is involved in cell-surface antigens. The constant regions are responsible for the unique structure and function of CD3D.

CD3D functions as the intracellular receptor for TCR signaling. It plays a critical role in the regulation of T-cell receptor complex (TCRC) assembly, activation, and proliferation. CD3D is part of the TCR complex, which consists of the T -cell receptor (TCR), a transmembrane protein that contains a variable region and a constant region, and the CD3D protein.

CD3D is involved in the regulation of TCR signaling through several mechanisms. Firstly, CD3D plays a role in the regulation of TCRC assembly by interacting with the TCR protein. Secondly, CD3D is involved in the regulation of TCRC activation by interacting with the co-stimulatory molecules, such as PD-L1. Finally, CD3D is involved in the regulation of TCRC proliferation by interacting with the transcription factor, NF-kappa-B.

CD3D as a Potential Drug Target

CD3D has been identified as a potential drug target due to its unique structure and function. The potential drug targets for CD3D are summarized in Table 1.

| Potential Drug Targets | CD3D Interactions |
| --- | --- |
| CD28 | Interacts with CD28 on PD-1+ T cells, which can enhance the sensitivity of these cells to PD-1 inhibitors. |
| PD-L1 | Interacts with PD-L1 on CD4+ T cells, which can enhance the inhibition of these cells by PD-1 inhibitors. |
| NF-kappa-B | Interacts with NF-kappa-B, which can enhance the transcriptional activity of these molecules. |

CD3D as a Potential Biomarker

CD3D has also been identified as a potential biomarker for T-cell receptor signaling. The levels of CD3D have been shown to be regulated by various factors, such as cytokines, growth factors, and chemokines. Therefore, the levels of CD3D can be used as a biomarker to monitor T-cell receptor signaling.

Conclusion

CD3D is a protein that plays a crucial role in the regulation of T-cell receptor signaling. Its unique structure and function make it a potential drug target or biomarker. The potential drug targets for CD3D and the biomarker properties of CD3D make it an attractive target for future research.

Protein Name: CD3 Delta Subunit Of T-cell Receptor Complex

Functions: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation, CD3D plays an essential role in thymocyte differentiation. Indeed, participates in correct intracellular TCR-CD3 complex assembly and surface expression. In absence of a functional TCR-CD3 complex, thymocytes are unable to differentiate properly. Interacts with CD4 and CD8 and thus serves to establish a functional link between the TCR and coreceptors CD4 and CD8, which is needed for activation and positive selection of CD4 or CD8 T-cells(PubMed:12215456)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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