Target Name: CD5L
NCBI ID: G922
Review Report on CD5L Target / Biomarker Content of Review Report on CD5L Target / Biomarker
CD5L
Other Name(s): CD5 antigen-like (isoform 1) | hAIM | apoptosis inhibitor expressed by macrophages | SP-alpha | AIM | IgM-associated peptide | apoptosis inhibitor 6 | Spalpha | CD5 molecule like, transcript variant 1 | apoptosis inhibitor of macrophage | CT-2 | CD5 antigen-like (scavenger receptor cysteine rich family) | igM-associated peptide | SP-ALPHA | Apoptosis inhibitor expressed by macrophages | API6 | CD5L variant 1 | PRO229 | CD5 antigen-like | CD5L_HUMAN | CD5 molecule like | Apoptosis inhibitor 6

CD5L: A Potential Drug Target and Biomarker

Introduction

CD5L, also known as CD5 antigen-like isoform 1, is a type of leukocyte differentiation antigen (CD5+) protein. CD5L plays an important role in the immune system and is involved in regulating the differentiation and function of immune cells. The expression level of CD5L changes in many inflammatory and immune diseases, therefore, it is of great clinical significance to study the role of CD5L in diseases and develop new treatment strategies.

Biological functions of CD5L

CD5L is an important molecule in the immune system. It is mainly involved in cell differentiation, proliferation and activation. The expression level of CD5L can be regulated in a variety of ways, including gene expression, protein translation and modification. Studies have shown that the expression level of CD5L is closely related to the differentiation and function of various immune cells, such as T cells, B cells, macrophages and dendritic cells.

Pathological significance of CD5L

CD5L plays an important role in many inflammatory and immune diseases. For example, in autoimmune diseases, CD5L expression levels are often elevated, leading to overactivation of the immune system and thus the development of the disease. In inflammatory bowel disease, CD5L expression levels are also often elevated, leading to an exacerbation of the inflammatory response.

Therapeutic implications of CD5L

Due to the important role of CD5L in the immune system, it is of great clinical significance to study the therapeutic potential of CD5L and develop new treatment strategies. Currently, several studies are exploring CD5L as a potential target for the treatment of immune diseases.

First, researchers are exploring CD5L as a potential target for treating autoimmune diseases. Some studies have shown that the expression level of CD5L is closely related to the occurrence and development of many autoimmune diseases, such as rheumatoid arthritis, animal autoimmune disease and multiple sclerosis. Therefore, researchers are exploring CD5L as a potential target for treating these diseases.

Second, researchers are exploring CD5L as a potential target for treating cancer. Studies have shown that the expression level of CD5L is closely related to the onset and development of many cancers, such as breast cancer, colon cancer and skin cancer. Therefore, researchers are exploring CD5L as a potential target for treating these cancers.

Third, researchers are exploring CD5L as a potential target for treating other diseases, such as cardiovascular disease, neurological disease, and metabolic disease.

Clinical applications of CD5L

Currently, CD5L has been studied in multiple clinical studies as a potential target for the treatment of many immune diseases and cancers. For example, several studies are exploring CD5L as a potential target for the treatment of multiple sclerosis (MS). In addition, some studies are exploring CD5L as a potential target for the treatment of other diseases, such as cardiovascular diseases, neurological diseases, and metabolic diseases.

Conclusion

CD5L is an important protein that plays an important role in the immune system and in pathology. The expression level of CD5L is closely related to the occurrence and development of various immune diseases and cancers. Therefore, it is of great significance to study the clinical significance of CD5L's biological functions, pathological significance, and therapeutic potential. With the continuous development of technology, researchers are exploring CD5L as a potential target for the treatment of immune diseases and cancer, bringing new hope for clinical treatment.

Protein Name: CD5 Molecule Like

Functions: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983)

The "CD5L Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CD5L comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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