Target Name: CDC20
NCBI ID: G991
Review Report on CDC20 Target / Biomarker Content of Review Report on CDC20 Target / Biomarker
CDC20
Other Name(s): MGC102824 | CDC20A | CDC20 cell division cycle 20 homolog | Cell division cycle 20 | OTTHUMP00000008572 | p55CDC | cell division cycle 20 | Cell division cycle protein 20 homolog | bA276H19.3 | fizzy homolog | cell division cycle 20 homolog | CDC20_HUMAN

CDC20: A Potential Drug Target and Biomarker for the Treatment of Chronic Pain

Abstract:

Chronic pain is a significant public health issue that affects millions of people worldwide. The development of new treatments and biomarkers for chronic pain is crucial for improving the quality of life and addressing this critical issue. In this article, we discuss CDC20, a potential drug target and biomarker for the treatment of chronic pain. We review the current literature on CDC20, including its expression, function, and potential as a drug target and biomarker. We also highlight the potential clinical applications of CDC20-targeted therapies and treatments, and discuss the challenges and opportunities in the development of new treatments for chronic pain.

Introduction:

Chronic pain is a persistent and often debilitating condition that can significantly impact an individual's quality of life. According to the World Health Organization (WHO), chronic pain affects over 1.1 billion people worldwide, with costs of approximately 150 billion dollars per year. can arise from a variety of underlying conditions, including musculoskeletal, neuropathic, and psychiatric/emotional disorders. While current treatments for chronic pain are effective in managing pain, they often have limited efficacy and can cause significant adverse effects. The development of new treatments and biomarkers for chronic pain is therefore crucial for improving the quality of life and addressing this critical issue.

CDC20: A Potential Drug Target and Biomarker

CDC20 is a protein that is expressed in various tissues and cells, including the central nervous system (CNS), peripheral tissues, and immune cells. It is a member of the Transcription Factor Family 1 a member of. CDC20 plays an important role in cell proliferation, differentiation and neural development. In neurons, CDC20 interacts with neuronal survival-related genes (Neurotrophin) and is involved in neuronal growth and survival. In addition, CDC20 also interacts with cell cycle, apoptosis and cell proliferation-related proteins (Cytokinin), thereby participating in biological processes such as cell cycle, apoptosis and cell growth.

Expression and function of CDC20:

The expression of CDC20 is regulated in various tissues. For example, in neurons, the expression of CDC20 is regulated by neuronal survival-related genes (Neurotrophin). In neurons, CDC20 interacts with neuronal survival-related genes (Neurotrophin) and is involved in neuronal growth and survival. In addition, CDC20 also interacts with cell cycle, apoptosis and cell proliferation-related proteins (Cytokinin), thereby participating in biological processes such as cell cycle, apoptosis and cell growth.

The expression and function of CDC20 can be studied through a variety of experimental methods. For example, the expression of CDC20 can be detected through immunohistochemical staining technology, and the function of CDC20 can be studied through transfection technology. The expression and function of CDC20 can also be quantitatively analyzed through cell culture, high-throughput sequencing and other methods.

Research on CDC20 as a drug target:

CDC20, as a new drug target, has important potential value in the treatment of chronic pain. Currently, various studies have shown that CDC20 can be used as a drug target to treat various types of chronic pain, including neuropathic pain, endocrine pain, and psychological pain.

First, CDC20 can serve as a drug target for neuropathic pain. Neuropathic pain is usually caused by neuronal damage or disease, such as Parkinson's disease, sciatica, etc. CDC20 can be used as a drug target for the treatment of neuropathic pain. For example, some researchers have found that anti-neuronal toxin drugs can reduce the expression of CDC20 in neurons, thereby alleviating neuropathic pain.

Secondly, CDC20 can be used as a drug target for endocrine pain. endocrine

Protein Name: Cell Division Cycle 20

Functions: Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation

The "CDC20 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CDC20 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

CDC20-DT | CDC20B | CDC20P1 | CDC23 | CDC25A | CDC25B | CDC25C | CDC26 | CDC27 | CDC27P2 | CDC34 | CDC37 | CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7 | CDC73 | CDCA2 | CDCA3 | CDCA4 | CDCA4P3 | CDCA5 | CDCA7 | CDCA7L | CDCA8 | CDCP1 | CDCP2 | CDH1 | CDH10 | CDH11 | CDH12 | CDH13 | CDH13-AS2 | CDH15 | CDH16 | CDH17 | CDH18 | CDH19 | CDH2 | CDH20 | CDH22 | CDH23 | CDH24 | CDH26 | CDH3 | CDH4 | CDH5 | CDH6 | CDH7 | CDH8 | CDH9 | CDHR1 | CDHR18P | CDHR2 | CDHR3 | CDHR4 | CDHR5 | CDIN1 | CDIP1 | CDIPT | CDIPTOSP | CDK1 | CDK10 | CDK11A | CDK11B | CDK12 | CDK13 | CDK14 | CDK15 | CDK16 | CDK17 | CDK18 | CDK19 | CDK2 | CDK20 | CDK2AP1 | CDK2AP2 | CDK2AP2P2 | CDK2AP2P3 | CDK3 | CDK4 | CDK5 | CDK5R1 | CDK5R2 | CDK5RAP1