Understanding NHERF2: A Gene with Multiple Functions (G9351)

Target Name: NHERF2

NCBI ID: G9351

NHERF2

Understanding NHERF2: A Gene with Multiple Functions

NHERF2 (N-Heterocysteine Reductase 2) is a gene that encodes a protein known as NHERF2. The protein produced by this gene has been shown to have various functions in the body, including regulating the production of stress hormones and protecting against oxidative stress.

One of the key functions of NHERF2 is its role in regulating the production of stress hormones. During times of stress, the body produces stress hormones to help it cope with the stressor. However, too much stress can lead to chronic stress, which can have negative impacts on both physical and mental health. NHERF2 has been shown to help regulate the production of stress hormones and prevent chronic stress.

Another function of NHERF2 is its role in protecting against oxidative stress. Oxidative stress occurs when the body's cells are exposed to damage from free radicals, which are unstable molecules that can cause inflammation and oxidative damage. Chronic oxidative stress has been linked to a number of diseases, including heart disease, diabetes, and cancer. NHERF2 has been shown to help protect against oxidative stress by regulating the production of reactive oxygen species (ROS) in cells.

In addition to its functions in regulating stress and protecting against oxidative stress, NHERF2 has also been shown to have potential as a drug target. The SIP1 protein produced by NHERF2 has been shown to interact with a number of different drugs, including the anti-inflammatory drug nonsteroidal anti-inflammatory drug (NSAID). This suggests that NHERF2 may be a useful target for drugs that are designed to reduce inflammation or protect against oxidative stress.

NHERF2 is also a potential biomarker for a number of diseases. For example, research has suggested that changes in the levels of NHERF2 may be an indicator of chronic stress in individuals. Additionally, changes in NHERF2 levels have been observed in a number of diseases, including heart disease, diabetes, and cancer. This suggests that NHERF2 may be a useful biomarker for these diseases and could be used as a target for new therapies.

In conclusion, NHERF2 is a gene that encodes a protein with various functions in the body, including regulating the production of stress hormones and protecting against oxidative stress. Its potential as a drug target and biomarker make it an attractive target for researchers and clinicians who are working to develop new treatments for a variety of diseases. Further research is needed to fully understand the role of NHERF2 in the body and its potential as a drug and biomarker.

Protein Name: NHERF Family PDZ Scaffold Protein 2

Functions: Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Necessary for cAMP-mediated phosphorylation and inhibition of SLC9A3 (PubMed:18829453). May also act as scaffold protein in the nucleus

The "NHERF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NHERF2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets