OTOF: A Protein Implicated in Neurological Disorders (G9381)

Target Name: OTOF

NCBI ID: G9381

OTOF

OTOF: A Protein Implicated in Neurological Disorders

OTOF (dfnb6) is a protein that is expressed in the brain and is known for its role in the development and progression of several neurological disorders, including Alzheimer's disease. The protein is a key component of the neural transmission system and is involved in the regulation of the movement of neurons and the formation of neural connections.

Research has shown that OTOF is abnormally expressed in the brains of individuals with Alzheimer's disease and that its levels are associated with the severity of the disease. Additionally, studies have also shown that OTOF is involved in the development of other neurological disorders, such as Parkinson's disease and multiple sclerosis.

Due to its involvement in the development and progression of these disorders, OTOF has been identified as a potential drug target. Researchers are currently studying the effects of drugs that target OTOF in order to develop new treatments for these disorders.

One of the main drug targets for OTOF is the use of small molecules, such as drugs that can modulate the activity of OTOF. These drugs can be used to treat symptoms of these disorders, such as memory loss, difficulty with movement, and changes in mood.

Another potential drug target for OTOF is the use of antibodies, such as those that are designed to target specific regions of OTOF. These antibodies can be used to block the activity of OTOF and prevent it from contributing to the development and progression of these disorders.

In addition to these drug targets, researchers are also studying the use of OTOF as a biomarker for the diagnosis and monitoring of these disorders. By analyzing the levels of OTOF in brain tissue and blood samples, researchers can determine the effectiveness of drugs and monitor the progression of the disease.

Overall, OTOF is a protein that is of great interest to researchers due to its involvement in the development and progression of several neurological disorders. The use of small molecules and antibodies to target OTOF is a promising approach to the development of new treatments for these disorders. Further research is needed to fully understand the role of OTOF in these disorders and to develop effective treatments.

Protein Name: Otoferlin

Functions: Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity)

The "OTOF Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about OTOF comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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