Target Name: P4HTM
NCBI ID: G54681
Review Report on P4HTM Target / Biomarker Content of Review Report on P4HTM Target / Biomarker
P4HTM
Other Name(s): prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | HIDEA | Prolyl hydroxlase domain-containing 4 | hypoxia-inducible factor prolyl hydroxylase 4 | PH4 | Proline 4-hydroxylase | P4H-TM | P4HTM variant 1 | EGLN4 | HIFPH4 | PHD4 | Hypoxia inducible factor prolyl 4 hydroxylase | Hypoxia-inducible factor prolyl hydroxylase 4 | proline 4-hydroxylase | PH-4 | HPH-4 | Prolyl 4-hydroxylase, transmembrane, transcript variant 1 | HIF-prolyl hydroxylase PH-4 | Hypoxia-inducible factor prolyl 4-hydroxylase | P4HTM_HUMAN | HIF-prolyl hydroxylase 4 | Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) | hypoxia-inducible factor prolyl 4-hydroxylase | P4HTM variant 3 | prolyl 4-hydroxylase, transmembrane | Prolyl 4-hydroxylase, transmembrane, transcript variant 3 | HIF-PH4 | P4H with transmembrane domain | Transmembrane prolyl 4-hydroxylase (isoform c) | Transmembrane prolyl 4-hydroxylase | Transmembrane prolyl 4-hydroxylase (isoform a)

P4HTM: A Drug Target / Disease Biomarker

P4HTM is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a potential drug target or biomarker that has been shown to play a role in a variety of biological processes, including inflammation, fibrosis, and neurodegeneration.

One of the key features of P4HTM is its ability to interact with a variety of different proteins, including those involved in the immune response, inflammation, and cell signaling. This makes P4HTM a potentially promising drug target, as it may be able to modulate the activity of these proteins without causing unintended side effects.

In addition to its potential drug-targeting properties, P4HTM has also been shown to be involved in a variety of biological processes that are important for human health. For example, it has been shown to play a role in the development and progression of fibrosis, which is a condition in which tissues become stiff and painful and can cause a range of problems, including heart failure, lung disease, and joint problems.

In addition to its role in fibrosis, P4HTM has also been shown to be involved in the development and progression of neurodegeneration, which is a condition in which the brain and other nervous cells are damaged or destroyed, leading to a range of problems, including cognitive impairment, weakness, and loss of motor function.

The potential drug targets for P4HTM are still being explored, but they are likely to be involved in a range of different biological processes, including inflammation, fibrosis, and neurodegeneration. As such, P4HTM is a potentially promising drug target that could be used to treat a variety of different conditions.

In conclusion, P4HTM is a protein that has been shown to play a role in a variety of biological processes that are important for human health. As such, it is a potentially promising drug target that could be used to treat a variety of different conditions. Further research is needed to fully understand its potential drug-targeting properties and to develop safe and effective treatments.

Protein Name: Prolyl 4-hydroxylase, Transmembrane

Functions: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex

The "P4HTM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about P4HTM comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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PA28 Complex | PA28gamma Complex | PA2G4 | PA2G4P1 | PA2G4P4 | PAAF1 | PABIR1 | PABIR2 | PABIR3 | PABP-dependent poly(A) nuclease (PAN) complex | PABPC1 | PABPC1L | PABPC1L2A | PABPC1L2B | PABPC1P10 | PABPC1P2 | PABPC1P4 | PABPC1P7 | PABPC3 | PABPC4 | PABPC4-AS1 | PABPC4L | PABPC5 | PABPN1 | PABPN1L | PACC1 | PACERR | PACRG | PACRG-AS2 | PACRGL | PACS1 | PACS2 | PACSIN1 | PACSIN2 | PACSIN3 | PADI1 | PADI2 | PADI3 | PADI4 | PADI6 | PAEP | PAEPP1 | PAF1 | PAF1 complex | PAFAH1B1 | PAFAH1B2 | PAFAH1B2P2 | PAFAH1B3 | PAFAH2 | PAG1 | PAGE1 | PAGE2 | PAGE2B | PAGE3 | PAGE4 | PAGE5 | PAGR1 | PAH | PAICS | PAICSP4 | PAIP1 | PAIP1P1 | PAIP2 | PAIP2B | PAK1 | PAK1IP1 | PAK2 | PAK3 | PAK4 | PAK5 | PAK6 | PAK6-AS1 | PALB2 | PALD1 | PALLD | PALM | PALM2 | PALM2AKAP2 | PALM3 | PALMD | Palmitoyltransferase | PALS1 | PALS2 | PAM | PAM16 | PAMR1 | PAN2 | PAN3 | PAN3-AS1 | Pancreas transcription factor 1 complex | PANDAR | PANK1 | PANK2 | PANK3 | PANK4 | Pantothenate Kinase | PANTR1 | PANX1 | PANX2 | PANX3