P2RY10: A drug target and biomarker for the treatment of chronic pain

Target Name: P2RY10

NCBI ID: G27334

P2RY10

P2RY10: A drug target and biomarker for the treatment of chronic pain

Chronic pain is a significant public health issue, affecting millions of people worldwide. The persistent nature of pain can lead to significant disability and decreased quality of life. The use of pain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and opioid combination products, can provide relief but can also have potential adverse effects. The development of drug targets and biomarkers for pain relief can provide new treatment options with reduced risk of adverse effects. P2RY10 is a protein that has been identified as a potential drug target and biomarker for the treatment of chronic pain.

P2RY10 function and localization

P2RY10 is a type-I transmembrane protein that is expressed in various tissues, including brain, heart, kidney, and liver. It is a G protein-coupled receptor (GPCR) that plays a role in pain signaling. P2RY10 is involved in the regulation of pain perception and neuroinflammation. It is highly expressed in the central nervous system (CNS) and has been localized to the basal ganglia, a region of the brain that is responsible for the control of movement and emotion.

P2RY10 is involved in the neurotransmitter systems that regulate pain, including dopamine and nitric oxide. It is a critical receptor for the neurotransmitter GABA, which is involved in the regulation of pain perception and neuroinflammation. GABA is known for its ability to inhibit pain signaling in the CNS. P2RY10 has been shown to play a role in the regulation of GABA signaling in the CNS, which may contribute to its potential as a pain relief drug.

P2RY10 as a drug target

The development of P2RY10 as a drug target is based on its involvement in pain signaling and its potential role in the regulation of GABA signaling. Several studies have shown that inhibition of P2RY10 can provide relief from pain in animal models of chronic pain, including pain caused by chemical irritants, thermal stimuli, and neuroinhibitors.

One of the potential benefits of P2RY10 as a drug target is its potential to reduce the risk of adverse effects associated with traditional pain medications. Nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids can cause significant adverse effects, including stomach ulcers, nausea, and constipation. By inhibiting P2RY10, pain relief can be achieved without these potential adverse effects.

Another potential benefit of P2RY10 as a drug target is its potential to treat chronic pain conditions that are not responding to traditional pain medications. Chronic pain conditions, such as neurogenic pain, cancer pain, and chronic low back pain, can be difficult to treat with traditional pain medications. By inhibiting P2RY10, pain relief can be achieved in these conditions.

P2RY10 as a biomarker

P2RY10 can also serve as a biomarker for the diagnosis and monitoring of chronic pain. The development of P2RY10 as a drug target and biomarker can provide new diagnostic tools for pain assessment, as well as new methods for monitoring the effectiveness of pain treatments.

Monitoring pain with P2RY10 can be done using various techniques, including dynamic whole-body scanning (DWBS), a non-invasive imaging technique that allows for the measurement of pain in all body areas. P2RY10 has been shown to be involved in the regulation of pain perception, which suggests that it may play a role in the development of pain. By inhibiting P2RY10, pain can be relieved, allowing for the assessment of pain levels.

In addition to its potential as a drug target and biomarker, P2RY10 is also a potential therapeutic target for the treatment of chronic pain. The development of P2RY10 inhibitors has the potential to provide new treatment options for chronic pain conditions, including neurogenic pain, cancer

Protein Name: P2Y Receptor Family Member 10

Functions: Putative receptor for purines coupled to G-proteins

The "P2RY10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about P2RY10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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