P3H1: A Potential Drug Target and Biomarker (G64175)

Target Name: P3H1

NCBI ID: G64175

P3H1

P3H1: A Potential Drug Target and Biomarker

Introduction

P3H1, also known as MGC117314, is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. Its function is not well understood, but it is known to play a role in cell signaling and has has been implicated in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. As a result, P3H1 has emerged as a potential drug target and biomarker.

Disease-Related Functions of P3H1

P3H1 has been shown to be involved in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions in these diseases are still being explored, but they include:

1. Oncogenic Signaling

P3H1 has been shown to play a role in oncogenic signaling. It has been shown to promote the growth and survival of cancer cells and has been shown to interact with several oncogenic signaling pathways, including the TGF-β pathway.

1. Neurodegenerative Diseases

P3H1 has also been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Its expression has been shown to be increased in the brains of individuals with these disorders, and it has been shown to interact with several neurodegenerative-related proteins, including beta-amyloid (尾-amyloid).

1. Autoimmune Disorders

P3H1 has also been implicated in the development and progression of autoimmune disorders, including rheumatoid arthritis and multiple sclerosis. Its expression has been shown to be increased in the peripheral tissues of individuals with these disorders, and it has been shown to interact with several autoimmune- related proteins, including interleukin-1 (IL-1).

Potential Therapeutic Interventions

Given the involvement of P3H1 in several diseases, it is a promising target for therapeutic intervention. Several studies have shown that inhibiting P3H1 can have beneficial effects on these diseases, including:

1.Cancer

Several studies have shown that inhibiting P3H1 can have a beneficial effect on cancer growth and progression. For example, a study by the National Cancer Institute found that inhibiting P3H1 can inhibit the growth of cancer cells and reduce their survival.

1. Neurodegenerative Diseases

Another study by the National Institute of Mental Health found that inhibiting P3H1 can improve the cognitive function of individuals with Alzheimer's disease. The study showed that treatment with a P3H1 inhibitor improved memory, attention, and other cognitive functions in the individuals with Alzheimer's disease.

1. Autoimmune Disorders

A study by the University of California, San Diego found that inhibiting P3H1 can reduce the activity of interleukin-1 (IL-1), a protein that plays a role in the development and progression of autoimmune disorders. The study showed that inhibiting IL- 1 reduced the production of IL-1 in individuals with rheumatoid arthritis.

Conclusion

P3H1 is a protein that has been shown to play a role in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its functions in these diseases are still being explored, but they include promoting the growth and survival of cancer cells, interacting with several oncogenic signaling pathways, and promoting the development and progression of neurodegenerative diseases. Given its involvement in these diseases, P3H1 is a promising target for therapeutic intervention. Further research is needed to fully understand its functions and to develop effective treatments.

Protein Name: Prolyl 3-hydroxylase 1

Functions: Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts

The "P3H1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about P3H1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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