Traf4's Role in Cancer Development (G9618)

Target Name: TRAF4

NCBI ID: G9618

TRAF4

Traf4's Role in Cancer Development

Traf4, also known as Malignant 62, is a protein that is expressed in a variety of human tissues, including cancer cells. It is a key regulator of cell division and has been implicated in the development and progression of many types of cancer.

One of the key features of Traf4 is its role in the G1/S transition, which is the process by which cells prepare for cell division. During the G1 phase, cells divide and prepare for cell division by producing copies of their chromosomes and increasing their size. In the S phase, the chromosomes are replicated and the cell divides.

Traf4 is a key regulator of the G1/S transition and has been shown to play a role in preventing cells from entering the S phase. This is important because when cells are able to divide, they are more likely to grow and develop into cancer. By preventing cells from entering the S phase, Traf4 may have a negative impact on the growth and survival of cancer cells.

Another way that Traf4 has been shown to influence cancer cell growth is through its role in the regulation of theNotch signaling pathway. Notch is a signaling pathway that is involved in the development and maintenance of tissues, including organs and limbs. Traf4 has been shown to play a key role in the regulation of Notch signaling and has been implicated in the development of many types of cancer.

In addition to its role in cell division and the Notch signaling pathway, Traf4 has also been shown to have other impacts on cancer cell growth and development. For example, Traf4 has been shown to play a role in the regulation of the invasion and metastasis capabilities of cancer cells. This is important because the ability of cancer cells to spread and establish new tumors is a major hallmark of cancer and is a key factor in the death and suffering caused by this disease.

Traf4 has also been shown to play a role in the regulation of the immune response, which is important for protecting the body against the development and progression of cancer. The immune system is a critical barrier against cancer and Traf4 has been shown to play a role in the development of immune evasion strategies by cancer cells.

In conclusion, Traf4 is a protein that has been shown to play a number of important roles in the development and progression of cancer. Its regulation of cell division, the Notch signaling pathway, and the immune response may be potential targets for the development of new cancer therapies. Further research is needed to fully understand the role of Traf4 in cancer and to develop effective treatments.

Protein Name: TNF Receptor Associated Factor 4

Functions: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273)

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