TRAJ19: A Non-Functional Gene Regulating T Cell Development (G28736)

Target Name: TRAJ19

NCBI ID: G28736

TRAJ19

Other Name(s): T cell receptor alpha joining 19 (non-functional)

TRAJ19: A Non-Functional Gene Regulating T Cell Development

T cell receptor alpha joining 19 (TRAJ19) is a non-functional gene that is located on chromosome 6p21. It is a member of the T cell receptor alpha (TCR伪) gene family, which is a critical regulator of T cell development and function. TCR伪 is a transmembrane protein that consists of an extracellular portion and an intracellular portion. The intracellular portion of TCR伪 contains a tyrosine kinase domain, which is responsible for the signaling of TCR伪 interactions with its downstream signaling molecules.

TRAJ19 is a non-functional gene that is located on chromosome 6p21 and encodes for a protein known as TCR伪-J, or TCR伪-Y, which is a critical regulator of T cell development and function. The TCR伪-J protein is a 21-kDa protein that is highly expressed in many tissues, including the brain, spleen, and Peyer's patches. It is also expressed in various cell types, including macrophages, dendritic cells, and B cells.

The TCR伪-J protein is composed of several subunits, including an N-terminal transmembrane domain, a catalytic tyrosine kinase domain, and a C-terminal T cell receptor alpha joining 19 (TCR伪-J) domain. The TCR伪-J domain is the site of TCR伪-J's signaling functions, including the regulation of T cell proliferation, differentiation, and selection.

Studies have shown that TCR伪-J is involved in the regulation of T cell receptor (TCR) signaling. TCR伪-J has been shown to play a role in the regulation of TCR伪 signaling by interacting with the TCR伪 co-receptor, PDCD1. This interaction between TCR伪-J and PDCD1 allows TCR伪-J to regulate the activity of TCR伪 and PDCD1, thereby modulating the strength and diversity of TCR signaling.

In addition to its role in TCR signaling, TCR伪-J is also involved in the regulation of various cellular processes, including cell adhesion, migration, and survival. TCR伪-J has been shown to interact with various cytoskeleton components, including microtubules and actin filaments, and has been shown to regulate the dynamics of these cytoskeleton components.

TRAJ19 is also of interest as a potential drug target or biomarker in the field of cancer. Several studies have shown that TCR伪-J is involved in the regulation of cancer cell growth, invasion, and metastasis. For example, it has been shown that high levels of TCR伪-J are associated with cancer cell poor prognosis, and that inhibition of TCR伪-J has been shown to be effective in treating various types of cancer.

In conclusion, T cell receptor alpha joining 19 (TRAJ19) is a non-functional gene that is located on chromosome 6p21 and encodes for a protein known as TCR伪-J, which is a critical regulator of T cell development and function. The TCR伪-J protein is involved in the regulation of TCR signaling, as well as various cellular processes, including cell adhesion, migration, and survival. TCR伪-J is also of interest as a potential drug target or biomarker in the field of cancer, and its inhibition has been shown to be effective in treating various types of cancer. Further research is needed to fully understand the role of TCR伪-J in T cell development and cancer progression.

Protein Name: T Cell Receptor Alpha Joining 19 (non-functional)

The "TRAJ19 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAJ19 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets