TRAPPC12: A Potential Drug Target and Biomarker (G51112)

Target Name: TRAPPC12

NCBI ID: G51112

TRAPPC12

TRAPPC12: A Potential Drug Target and Biomarker

TRAPPC12, or Tetratricopeptide Repeat Protein 12, is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure, which consists of four repeating polypeptide units, making It becomes a very attractive object of study. This article will introduce in detail the structure, function, potential as a drug target and application prospects as a biomarker of TRAPPC12.

1. Structure and function

TRAPPC12 is a polypeptide with a length of 15.5 kDa, which consists of four repeating polypeptide units, namely 伪-helix, 尾-sheet and two convolutions. This complex structure gives TRAPPC12 a strong three-dimensional structure, making it a challenging protein to engineer.

The function of TRAPPC12 is mainly reflected in its role as a signaling molecule. Within cells, TRAPPC12 can interact with other proteins and thus participate in a variety of biological processes. For example, TRAPPC12 can bind to receptor-coupled receptors (such as PD-L1) on the cell membrane to promote interactions between cells and immune cells. In addition, TRAPPC12 can also be used as a marker of intracellular protein localization for cell biology research and bioinformatics analysis.

2. Potential as a drug target

TRAPPC12 has multiple advantages as a potential drug target. First, because TRAPPC12 is expressed in a variety of cancers, it may become a widely used target in cancer therapy. Secondly, the complex structure of TRAPPC12 makes it highly plastic and can adapt to a variety of different drug intervention methods. Finally, TRAPPC12 expression is increased in a variety of neurological diseases, providing new ideas for the development of drugs to treat these diseases.

At present, drug research on TRAPPC12 mainly focuses on the following aspects:

1. Drug screening: Use TRAPPC12 as a target to develop a drug screening strategy to screen out compounds with potential therapeutic effects from a variety of drugs.

2. Mechanism of action: Study the mechanism of action of TRAPPC12, reveal its mode and mechanism of action in the organism, and provide a theoretical basis for drug development.

3. Drug intervention: Through gene editing technology, TRAPPC12 is modified to make it more susceptible to drug intervention, providing new methods for drug treatment.

3. Application prospects as biomarkers

As a complex protein, TRAPPC12 has a variety of potential applications. In tumor research, TRAPPC12 can be used as a biomarker for the difference between tumor cells and normal cells, and can be used for early diagnosis, treatment effect evaluation and recurrence monitoring of tumors. In neurological disease research, TRAPPC12 can be used as a biomarker of neuronal damage and abnormal nerve gyrification for the research and treatment of neurodegenerative diseases.

In addition, TRAPPC12 can also be used as a biomarker for immune cell function assessment and used to monitor immune cell differentiation and function. In liver disease research, TRAPPC12 can be used as a biomarker of liver damage and liver disease progression for the diagnosis and treatment of liver diseases.

4. Conclusion

TRAPPC12 is a protein with complex structure and multiple functions, and its potential as a drug target and application prospects as a biomarker have aroused widespread research interest. With the continuous development of technology, the biological functions of TRAPPC12 are expected to be further revealed in the future, bringing more hope to human health.

Protein Name: Trafficking Protein Particle Complex Subunit 12

Functions: Component of the TRAPP complex, which is involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage (PubMed:21525244, PubMed:28777934). Also plays a role in chromosome congression, kinetochore assembly and stability and controls the recruitment of CENPE to the kinetochores (PubMed:25918224)

The "TRAPPC12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TRAPPC12 comprehensively, including but not limited to:
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•   the target screening and validation;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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