Mical2: A Protein with Potential as A Drug Target and Biomarker

Target Name: MICAL2

NCBI ID: G9645

MICAL2

Mical2: A Protein with Potential as A Drug Target and Biomarker

Mical2 (DKFZp686H2469) is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and kidneys. It is a member of the MIC (middleknotin) family of proteins, which are known for their role in regulating cell signaling pathways. Mical2 has been shown to play a role in several cellular processes, including cell adhesion, migration, and invasion.

One of the most promising aspects of Mical2 is its potential as a drug target. The MIC family of proteins has been shown to be involved in a wide range of physiological processes, including cell signaling, cytoskeletal organization, and cell survival. As such, Mical2 has been targeted by several research groups to study its potential functions and to investigate its potential as a drug.

One of the main research efforts focused on Mical2 has been the development of small molecule inhibitors of Mical2, which can be used to inhibit its activity and study its underlying mechanisms. These inhibitors have been shown to be effective in a variety of cellular assays, including cell-based assays, biochemical assays, and in animal models of disease.

In addition to its potential as a drug, Mical2 has also been studied as a biomarker for several diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Mical2 has been shown to be expressed in a wide range of tissues and to be involved in several cellular processes that are relevant to these diseases. As such, Mical2 has the potential to serve as a diagnostic or therapeutic target in these diseases.

Overall, Mical2 is a protein that has generated a great deal of interest and activity in the scientific community due to its potential role in cellular signaling pathways and its potential as a drug target or biomarker. Further research is needed to fully understand its mechanisms of action and to explore its potential in a variety of cellular and biological processes.

Protein Name: Microtubule Associated Monooxygenase, Calponin And LIM Domain Containing 2

Functions: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334)

The "MICAL2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MICAL2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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