Rab11FIP3: A Potential Drug Target Or Biomarker (G9727)

Target Name: RAB11FIP3

NCBI ID: G9727

RAB11FIP3

Rab11FIP3: A Potential Drug Target Or Biomarker

RAB11FIP3 is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. Its full name is Rab11-associated protein 3, and it is also known as arfophilin-1. This protein is of interest as a potential drug target or biomarker due to its unique structure and its involvement in various physiological processes in the body.

Structure and Function

Rab11FIP3 is a 21 kDa protein that is composed of 156 amino acid residues. It has a unique structure that consists of a long N-terminus, a middle alpha-helices region, and a C-terminus. The N-terminus of Rab11FIP3 contains a putative N-acyl transferase (NAT) domain, which is known to be involved in protein-protein interactions. The middle alpha-helices region contains three conserved helices that are involved in the formation of a distinct 尾-sheet. The C-terminus of Rab11FIP3 contains a unique C-tail that is composed of a conserved glycine-rich region and a short terminal extension that is rich in electrolytes.

In terms of its function, Rab11FIP3 is involved in various physiological processes in the body. For example, it is involved in the regulation of mitochondrial fusion and fusion, which is critical for energy metabolism. It is also involved in the regulation of cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key factor in the development and maintenance of tissues in the body.

Drug Targeting and Biomarker

Due to its unique structure and its involvement in various physiological processes, Rab11FIP3 is a promising drug target or biomarker. Studies have shown that inhibiting Rab11FIP3 can lead to a variety of cellular and molecular changes, including the inhibition of mitochondrial fusion and the inhibition of cellular signaling pathways.

One potential mechanism by which Rab11FIP3 can be targeted is through its involvement in the regulation of mitochondrial fusion. Mitochondrial fusion is a critical process for energy metabolism, and the regulation of this process is critical for the survival and growth of cells. Studies have shown that inhibiting Rab11FIP3 can lead to a reduction in the fusion rate of mitochondria, which can lead to a reduction in cellular energy production.

Another potential mechanism by which Rab11FIP3 can be targeted is through its involvement in cellular signaling pathways. The TGF-β pathway is a key regulator of cell growth, differentiation, and survival, and is involved in the development and maintenance of tissues in the body. Studies have shown that Rab11FIP3 is involved in the regulation of TGF-β signaling, and that inhibiting this signaling pathway can lead to a variety of cellular and molecular changes.

In addition to its potential drug-targeting properties, Rab11FIP3 is also a potential biomarker. The regulation of mitochondrial fusion and the TGF-β pathway are critical processes that are involved in the development and maintenance of tissues in the body, and therefore, changes in these processes can be used as biomarkers for a variety of diseases, including cancer, cardiovascular disease, and neurodegenerative diseases.

Conclusion

Rab11FIP3 is a protein that is expressed in various tissues throughout the body and is involved in various physiological processes in the body. Its unique structure and its involvement in the regulation of mitochondrial fusion and the TGF-β pathway make it a promising drug target or biomarker. The inhibition of Rab11FIP3 has been shown to lead to a variety of cellular and molecular changes, including the inhibition of mitochondrial fusion and the inhibition of cellular signaling pathways. Further studies are needed to fully understand the

Protein Name: RAB11 Family Interacting Protein 3

Functions: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494)

The "RAB11FIP3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAB11FIP3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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