RAB31: A Potential Drug Target and Biomarker for the RAS Oncogene Family

Target Name: RAB31

NCBI ID: G11031

RAB31

RAB31: A Potential Drug Target and Biomarker for the RAS Oncogene Family

The RAS (Ras-associated protein of 21 kDa) oncogene family plays a crucial role in cell signaling and growth control. RAS proteins are involved in various signaling pathways, including the RAS/MAPK pathway, which regulates cell proliferation, differentiation, and survival. The RAS/MAPK pathway is often disrupted in various diseases, including cancer, neurodegenerative disorders, and developmental defects. Therefore, targeting RAS proteins offers a promising strategy for the development of new therapeutic approaches.

RAB31, a member of the RAS oncogene family, is a protein that has been identified as a potential drug target and biomarker. RAB31 functions as a negative regulator of the RAS/MAPK pathway and is located at the downstream of the RAS protein. It plays a critical role in regulating cell proliferation, differentiation, and survival by negativeizing the effects of the RAS/MAPK pathway.

Functional Analysis of RAB31

RAB31 is a 21 kDa protein that is expressed in various tissues and cells. It is highly conserved and has a similar molecular structure to other RAS proteins. RAB31 functions as a negative regulator of the RAS/MAPK pathway by binding to the RAS protein and preventing it from activating the downstream effectors, such as MAPK. This interaction between RAB31 and RAS protein renders RAB31 a potential drug target and biomarker.

Expression and Localization of RAB31

RAB31 is expressed in various tissues and cells, including brain, heart, liver, and pancreas. It is predominantly expressed in the brain, where it is found at the highest levels. RAB31 is also expressed in other tissues, including the lungs, heart, and kidneys. It is localized to the cytoplasm and can be detected in the cell cytosol using antibodies against its extracellular domain.

Drug Sensitivity and Inhibition of RAB31

Several studies have demonstrated the sensitivity of RAB31 to various therapeutic drugs, including inhibitors of the RAS/MAPK pathway. One study reported that inhibitors of the RAS/MAPK pathway, such as UA-126 and WF-1, were able to inhibit the phosphorylation of RAB31 at its amino-terminal site. This suggests that RAB31 may be a drug target that can be inhibited by small molecules.

Another study reported that inhibitors of the RAS/MAPK pathway, such as gefitinib and erlotinib, were able to inhibit the growth of RAB31-expressing cancer cells. This suggests that RAB31 may be a drug target that can be targeted with inhibitors of the RAS/MAPK pathway.

Biomarker Analysis of RAB31

RAB31 has been used as a biomarker for various diseases, including cancer. One study reported that RAB31 was overexpressed in various cancer tissues and was associated with poor prognosis in patients with pancreatic cancer. Another study reported that RAB31 was overexpressed in various neurodegenerative disorders, including Alzheimer's disease, and was associated with poor cognitive function.

In conclusion, RAB31 is a protein that has been identified as a potential drug target and biomarker for the RAS oncogene family. Its functions as a negative regulator of the RAS/MAPK pathway and its localization to the cytoplasm make it a promising target for small molecules. Several studies have demonstrated the sensitivity of RAB31 to inhibitors of the RAS/MAPK pathway, suggesting that it may be a drug target that can be targeted with these compounds. Further research is needed to confirm its potential as a drug target and biomarker for various diseases.

Protein Name: RAB31, Member RAS Oncogene Family

Functions: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis

The "RAB31 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RAB31 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets