RAB29: A Potential Drug Target for Cellular Signaling Pathways

Target Name: RAB29

NCBI ID: G8934

RAB29

RAB29: A Potential Drug Target for Cellular Signaling Pathways

RAB29 (RAB7L1) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Rab family of small GTPases, which are a group of transmembrane proteins that regulate various cellular processes. One of the functions of RAB29 is to regulate the entry of nutrients into cells, which is important for maintaining cellular homeostasis and survival.

RAB29 is also known as RAB7L1, which is a splicing variant of the RAB29 gene. The RAB29 gene is located on chromosome 18 and has 21 exons. The RAB29 protein has a molecular weight of approximately 41 kDa and a calculated pI of 6.3. RAB29 is a glycophosphorylated protein, which means that it has a phosphate groups attached to its amino acids. These phosphate groups can modulate the activity of RAB29 and interact with other proteins.

RAB29 is involved in many different cellular processes in the body, including the regulation of mitochondrial fusion and the maintenance of cellular signaling pathways. It is a component of several different signaling pathways, including the TOR signaling pathway and the PI3K/Akt signaling pathway. RAB29 has also been shown to play a role in the regulation of cellular transport processes, such as the uptake of nutrients and the export of waste products.

One of the potential applications of RAB29 as a drug target is its role in the regulation of cellular signaling pathways. Many diseases are caused by the disruption of normal cellular signaling pathways, and RAB29 may be a useful target for the development of new treatments. For example, RAB29 has been shown to play a role in the regulation of cell proliferation and has been linked to the development of various types of cancer. Therefore, targeting RAB29 with drugs that can inhibit its activity may be a promising strategy for the treatment of cancer.

Another potential application of RAB29 as a drug target is its role in the regulation of mitochondrial function. Mitochondria are organelles that are responsible for generating energy for the cell and are involved in the regulation of many cellular processes, including metabolism and cell death. RAB29 is involved in the regulation of mitochondrial fusion, which is the process by which two mitochondria fuse to form one. This process is important for the production of ATP, which is the energy currency of the cell. Therefore, targeting RAB29 with drugs that can modulate its activity in the regulation of mitochondrial fusion may be a promising strategy for the treatment of various diseases that are caused by disruptions in mitochondrial function.

In addition to its role in the regulation of mitochondrial function, RAB29 may also be a potential drug target for its role in the regulation of cellular signaling pathways. RAB29 has been shown to play a role in the regulation of cellular signaling pathways, including the TOR signaling pathway and the PI3K/Akt signaling pathway. These pathways are involved in the regulation of cellular processes such as cell growth, metabolism, and survival. Therefore, targeting RAB29 with drugs that can inhibit its activity in these pathways may be a promising strategy for the treatment of various diseases.

The regulation of cellular signaling pathways is a complex process that is regulated by many different factors, including the levels of various signaling molecules and the presence of intracellular signaling pathways. RAB29 is involved in the regulation of

Protein Name: RAB29, Member RAS Oncogene Family

Functions: The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   advantages and risks of development, etc.
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