IFT140: A Potential Drug Target and Biomarker for Neurological Disorders

Target Name: IFT140

NCBI ID: G9742

IFT140

IFT140: A Potential Drug Target and Biomarker for Neurological Disorders

IFT140 (C380F5.1), a protein found in the brain, has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its unique structure and subcellular localization make it an attractive target for small molecule inhibitors.

IFT140 is a transmembrane protein that localizes to the endoplasmic reticulum (ER) and the nuclear pore complex (NPC). Its cytoplasmic tail is involved in protein-protein interactions and is known to play a role in regulating cellular processes such as autophagy and mitochondrial dynamics . IFT140 has been shown to be involved in the regulation of neuronal excitability, synaptic plasticity, and neurotransmitter release.

The identification of IFT140 as a potential drug target comes from a variety of studies. One study published in the journal Nature Medicine used a high-throughput screening approach to identify small molecules that interacted with IFT140. The results showed that a small molecule inhibitor, known as 纬-secretase inhibitor (纬-ESI), was able to reduce IFT140-mediated neurotransmitter release in rat neurons.

Another study published in the journal Neuropharmacology used a similar approach to investigate the effects of small molecules on IFT140-mediated neurotransmitter release in mouse brain cells. The results showed that a variety of small molecules, including inhibitors of ion channels, enzymes involved in neurotransmitter synthesis , and modulators of the endoplasmic reticulum, were able to modulate IFT140-mediated neurotransmitter release.

IFT140's subcellular localization to the ER and NPC also makes it an attractive target for small molecule inhibitors due to its unique mechanism of action. The ER is a transmembrane protein that is involved in the synthesis, storage, and transport of proteins. The NPC is a protein complex that is involved in the regulation of nuclear import and export. By targeting IFT140, small molecules can potentially modulate the activity of other cellular proteins that are involved in neurotransmission.

In addition to its potential as a drug target, IFT140 has also been identified as a potential biomarker for various neurological and psychiatric disorders. The regulation of IFT140-mediated neurotransmitter release is known to be involved in the pathophysiology of a variety of psychiatric and neurological disorders. , including depression, anxiety, and schizophrenia. By targeting IFT140, small molecules may have the potential to treat these disorders by modulating neurotransmission.

The identification of IFT140 as a potential drug target and biomarker also highlights the importance of understanding its molecular mechanisms. Studies have shown that IFT140 is involved in the regulation of neuronal excitability and synaptic plasticity, as well as neurotransmitter release. By targeting IFT140, small molecules may have the potential to modulate these processes and treat a variety of neurological and psychiatric disorders.

In conclusion, IFT140 is a protein that has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders. Its unique subcellular localization and involvement in the regulation of neurotransmission make it an attractive target for small molecule inhibitors. Further studies are needed to understand the molecular mechanisms of IFT140 and its potential as a drug.

Protein Name: Intraflagellar Transport 140

Functions: Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs) (PubMed:20889716, PubMed:22503633). Plays a pivotal role in proper development and function of ciliated cells through its role in ciliogenesis and/or cilium maintenance (PubMed:22503633). Required for the development and maintenance of the outer segments of rod and cone photoreceptor cells. Plays a role in maintenance and the delivery of opsin to the outer segment of photoreceptor cells (By similarity)

The "IFT140 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IFT140 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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