Unlocking the Potential of DNAJC3 (P58) as a Drug Target and Biomarker

Target Name: DNAJC3

NCBI ID: G5611

DNAJC3

Unlocking the Potential of DNAJC3 (P58) as a Drug Target and Biomarker

Introduction

DNAJC3 (P58) is a protein that is expressed in various tissues and cells throughout the body. Its primary function is to regulate microtubules, which are essential for cell division and transport of organelles within the cell.DNAJC3 has been identified as a potential drug target and biomarker due to its unique structure, expression pattern, and involvement in various cellular processes.

Structure and Expression

DNAJC3 is a 21-kDa protein that contains 106 amino acid residues. It has a unique fold that is composed of a parallel beta-sheet and a beta-strand. The protein has a highly conserved structure, with a calculated pI of 9.67 Namor. DNAJC3 is expressed in a variety of cells, including neurons, liver cells, and muscle cells. Its expression levels vary in different tissues and physiological conditions, providing opportunities to study its function.

Function and Potential Therapeutic Applications

DNAJC3 plays a crucial role in regulating microtubule dynamics and stability. It is a key component of the mitotic spindle, which is responsible for organizing the sister chromatids during cell division. Meticulous regulation of microtubule dynamics is essential for proper cell division, which is critical for maintaining tissue homeostasis and cell survival.

DNAJC3 is also involved in the regulation of the cytoskeleton, which is responsible for the structural integrity of the cell. The cytoskeleton provides mechanical tension that helps maintain the cell's shape and stability, and it also plays a role in the transport of vesicles and organelles within the cell.

In addition to its role in cell division and cytoskeleton regulation, DNAJC3 is also involved in the regulation of cellular signaling pathways. It has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, which is a critical pathway involved in the regulation of cellular processes such as cell growth, differentiation, and survival.

Potential Drug Targets

DNAJC3's unique structure and function make it an attractive target for drug development. Several studies have identified potential drug compounds that can inhibit DNAJC3's activity. These compounds have been shown to have either tailing effect (the compound is attached to the end of the target protein , affecting its activity) or blocking effect (the compound prevents the protein from functioning altogether).

One of the most promising compounds is a small molecule called NBQ1, which is a potent inhibitor of DNAJC3. NBQ1 has been shown to block the assembly and stability of microtubules, which is consistent with its function as a protein that regulates microtubule dynamics.

Another compound that has shown promise is a peptide called P217. P217 is a fragment of DNAJC3 that has been shown to inhibit the activity of DNAJC3 in cell experiments.

Biomarkers

DNAJC3 is also an attractive biomarker for the diagnosis and prognosis of various diseases. Its involvement in various cellular processes makes it a potential target for diagnostic biomarkers.

For example, DNAJC3 has been shown to be involved in the regulation of the mitotic spindle, which is a critical structure that is affected in various types of cancer. Therefore, its levels may be used as a biomarker for the diagnosis and prognosis of these diseases.

Conclusion

DNAJC3 is a protein that has unique structure and function, making it an attractive target for drug development. Its role in regulating microtubule dynamics and stability, as well as its involvement in various cellular signaling pathways, making it a potential drug

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member C3

Functions: Involved in the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Acts as a negative regulator of the EIF2AK4/GCN2 kinase activity by preventing the phosphorylation of eIF-2-alpha at 'Ser-52' and hence attenuating general protein synthesis under ER stress, hypothermic and amino acid starving stress conditions (By similarity). Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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