DNAJC25: A promising drug target and biomarker for DNAJ heat shock protein family

Target Name: DNAJC25

NCBI ID: G548645

DNAJC25

DNAJC25: A promising drug target and biomarker for DNAJ heat shock protein family

Heat shock proteins (HSPs) are a family of proteins that play a crucial role in maintaining the stability and integrity of cellular structures and function, particularly during times of increased environmental stress, such as temperature and hyperactivity. One of the well-known HSPs is the DNAJ heat shock protein family (Hsp40), which is characterized by the presence of a heat shock domain (HSP70/HSP40) and a catalytic domain. Hsp40s are involved in a wide range of cellular processes, including DNA replication, transcription, and repair, and are often considered as potential drug targets or biomarkers due to their unique structure and function.

In this article, we will focus on DNAJC25, a member of the DNAJ heat shock protein family and a promising drug target or biomarker. We will explore its structure, function, and potential applications in drug development.

Structure and localization

DNAJC25 is a 25kDa protein that contains a N-terminal catalytic domain, a C-terminal DNA-binding domain, and a variable N-terminal region. The catalytic domain is composed of a unique farnesylated cysteine residue, which is known to enhance the protein's stability and stability-dependent catalytic activity. DNAJC25 is predominantly localized to the cytoplasm, where it is involved in various cellular processes, including DNA replication, transcription, and repair.

Function

DNAJC25 is involved in the regulation of DNA replication, specifically in the checkpoint step of the DNA replication process. Checkpoint is a critical process for ensuring that each new DNA molecule is properly replicated and that any errors or mutations are detected and repaired before the cell divides. DNAJC25 plays a crucial role in checkpoint regulation by participating in the checkpoint protein complex, which is responsible for monitoring the integrity of the double helix during DNA replication.

In addition to its role in checkpoint regulation, DNAJC25 is also involved in the regulation of DNA transcription. DNAJC25 has been shown to interact with the transcription factor, p53, and play a role in the regulation of p53-mediated gene expression.

Potential applications

DNAJC25's unique structure and function make it an attractive drug target or biomarker. The potential applications of DNAJC25 as a drug target are vast, including the treatment of various diseases, such as cancer, neurodegenerative diseases, and autoimmune diseases.

One of the primary benefits of targeting DNAJC25 is its potential to inhibit its catalytic activity, which could lead to the inhibition of cellular processes that are critical for the disease. For example, DNAJC25 has been shown to be involved in the regulation of cell division, and inhibiting its catalytic activity could lead to a reduction in cell proliferation.

Another potential application of DNAJC25 as a drug target is its role in the regulation of DNA replication. DNAJC25 has been shown to participate in the checkpoint protein complex, which is responsible for monitoring the integrity of the double helix during DNA replication. By inhibiting its catalytic activity, DNAJC25 could lead to a reduction in the accuracy and efficiency of DNA replication, which could have a therapeutic impact on various diseases, including cancer.

DNAJC25 has also been shown to play a role in the regulation of DNA transcription. Interactions with transcription factors, such as p53, have been described, and DNAJC25 has been shown to play a role in the regulation of p53-mediated gene expression.

In conclusion, DNAJC25 is a promising drug target or biomarker due to its unique structure and function. Its potential applications in drug development are vast, and its ability to regulate various cellular processes makes it an attractive target for small molecule inhibitors or biologics. Further research is needed to fully understand its role in cellular processes and its potential as a drug.

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member C25

The "DNAJC25 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DNAJC25 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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