DNAJC11: Potential Drug Target for Aging and Age-Related Diseases

Target Name: DNAJC11

NCBI ID: G55735

DNAJC11

DNAJC11: Potential Drug Target for Aging and Age-Related Diseases

DNAJC11 (OTTHUMP00000001586) is a protein that is expressed in various tissues throughout the body, including muscle, heart, brain, and organs. Its primary function is to regulate the activity of the myosin-associated protein (MAP) complex, which is responsible for muscle contractions. DNAJC11 has been identified as a potential drug target due to its involvement in various cellular processes that are associated with aging and age-related diseases, such as muscle wasting, heart failure, and neurodegeneration.

The MAP protein complex is a critical regulator of muscle function that is responsible for generating the force needed for muscle contractions. DNAJC11 is a key component of the MAP complex, and its absence or dysfunction has been implicated in the development of various muscle-related conditions, including muscle wasting, also known as muscle atrophy, which is a common condition in older adults.

DNAJC11 plays a crucial role in the regulation of muscle protein synthesis and degradation. It is known to interact with the protein Myosin light chain, which is a key component of the MAP complex. This interaction is important for the regulation of muscle protein synthesis and degradation, as well as for the maintenance of muscle mass and function.

In addition to its role in muscle function, DNAJC11 is also involved in the regulation of various cellular processes that are associated with aging and age-related diseases. For example, it has been shown to be involved in the regulation of cellular processes that are associated with the aging process, such as the accumulation of intracellular aggregates, also known as \"age-related protein misfolding,\" which is a hallmark of aging.

DNAJC11 has also been shown to be involved in the regulation of various signaling pathways that are associated with aging and age-related diseases, such as the TOR signaling pathway. This pathway is involved in the regulation of cell growth, metabolism, and survival, and is thought to play a key role in the regulation of aging.

In conclusion, DNAJC11 is a protein that is involved in various cellular processes that are associated with aging and age-related diseases. Its involvement in the regulation of muscle function, as well as its involvement in the regulation of cellular processes that are associated with aging, makes it a potential drug target. Further research is needed to fully understand the role of DNAJC11 in these processes, as well as its potential as a drug target.

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member C11

Functions: Required for mitochondrial inner membrane organization. Seems to function through its association with the MICOS complex and the mitochondrial outer membrane sorting assembly machinery (SAM) complex

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•   general information;
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•   the target screening and validation;
•   expression level;
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