DNAJC18: A promising drug target and biomarker for DNA damage repair and cell survival

Target Name: DNAJC18

NCBI ID: G202052

DNAJC18

Other Name(s): DnaJ heat shock protein family (Hsp40) member C18 | DnaJ (Hsp40) homolog, subfamily C, member 18 | DJC18_HUMAN | DnaJ (Hsp40) homolog subfamily C member 18 (DNAJC18) | DnaJ homolog subfamily C member 18

DNAJC18: A promising drug target and biomarker for DNA damage repair and cell survival

DNA damage repair and cell survival are crucial processes in maintaining the integrity of cellular homeostasis. DNA double-strand breaks (DSBs) are the most common types of DNA damage, which can lead to the loss of genetic information and the disruption of cellular processes. The DNAJC18 (DnaJ heat shock protein family (Hsp40) member C18) protein plays a vital role in repairing DNA DSBs and maintaining cellular survival.DNAJC18 is a heat-induced protein that contains a unique domain that enables it to interact with damaged DNA and facilitate the repair process.

In this article, we will explore the biology of DNAJC18, its function in DNA damage repair, and its potential as a drug target or biomarker.

Biogenesis and localization

DNAJC18 is a 21-kDa protein that is expressed in various cell types, including eukaryotic cells, bacteria, and yeast. It is highly heat-inducible and can be expressed in high levels following exposure to heat or other stressors.DNAJC18 is predominantly localized to the cytoplasm of the cells, where it can interact with damaged DNA and participate in the DNA damage repair process.

Function and mechanism

DNAJC18 is a critical protein for DNA damage repair, as it can facilitate the process of homologous recombination (HR) in the presence of double-strand breaks. HR is a critical repair mechanism that allows for the accurate reconstruction of the double-strand break in the damaged DNA.DNAJC18 has been shown to interact with damaged DNA and promote the formation of a double-strand break.

In addition to its role in repair, DNAJC18 has also been shown to play a critical role in the regulation of cell survival. It has been shown to be involved in various cellular processes, including cell growth, apoptosis, and autophagy. DNAJC18 has been shown to promote the formation of a protein-protein interaction network, which is crucial for its localization and function.

Drug targeting

DNAJC18 has been identified as a potential drug target due to its unique mechanism of action in DNA damage repair. Methods such as in vitro drug screening have shown that inhibitors of DNAJC18 can significantly reduce the levels of damaged DNA and increase the rate of HR. Furthermore, in vivo experiments have shown that these inhibitors can significantly reduce the incidence of DNA-damaged cells and improve the lifespan of the animals.

Biomarker potential

DNAJC18 has also been identified as a potential biomarker for DNA damage repair. The level of DNAJC18 in the cytoplasm of damaged cells can be used as a marker for the severity of DNA damage. Experiments have shown that the level of DNAJC18 in the cytoplasm of damaged cells is significantly increased compared to the level of DNAJC18 in the cytoplasm of undamaged cells.

Conclusion

In conclusion, DNAJC18 is a critical protein for DNA damage repair and cell survival. Its unique mechanism of action in DNA damage repair makes it a promising drug target and biomarker. Further research is needed to fully understand the role of DNAJC18 in cellular processes and its potential as a drug.

Protein Name: DnaJ Heat Shock Protein Family (Hsp40) Member C18

Functions: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection (PubMed:25631089). Regulates the recruitment of DNAJB12:DNAJB14 into SV40-induced foci and all cooperate to guide SV40 across the endoplasmic reticulum membrane. The foci represent the site from which SV40 penetrates into the cytosol (PubMed:25631089)

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