ABCC3: A Multi-Specific Organic Anion Transporter D as a Drug Target or Biomarker

Target Name: ABCC3

NCBI ID: G8714

ABCC3

ABCC3: A Multi-Specific Organic Anion Transporter D as a Drug Target or Biomarker

ABCC3 (ATP-Binding C3-Type Reductase) is a transmembrane protein that belongs to the family of ATP-binding cassette (ABC) proteins. These proteins are involved in various cellular processes, including intracellular signaling, protein transport, and cellular signaling pathways. ABCC3 is expressed in many different tissues and cells, including the brain, heart, kidney, and liver. Its function in cellular signaling is well-studied, and it has been implicated in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Recently, researchers have discovered that ABCC3 is a drug target and a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. This has led to a growing interest in the study of ABCC3 and its potential as a therapeutic target or biomarker.

Drug Targets

ABCC3 has been identified as a potential drug target due to its unique function in cellular signaling. The ability of ABCC3 to regulate intracellular signaling pathways and to interact with various signaling molecules, including tyrosine kinases and ion channels, makes it an attractive target for small molecules and antibodies.

ABCC3 has been shown to play a role in various signaling pathways, including the PI3K/Akt signaling pathway, which is involved in cell survival, proliferation, and angiogenesis. Additionally, ABCC3 has been shown to regulate the TGF-灏? signaling pathway, which is involved in cell growth, differentiation, and inflammation.

Biomarkers

ABCC3 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The ability of ABCC3 to regulate intracellular signaling pathways and to interact with various signaling molecules makes it an attractive target for diagnostic biomarkers.

Studies have shown that ABCC3 has been expressed in various tissues and cells, including cancer cells, neurodegenerative diseases, and autoimmune disorders. Additionally, studies have shown that ABCC3 can be used as a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, researchers have shown that ABCC3 can be used as a biomarker for cancer by regulating the cell cycle and apoptosis.

Potential Therapeutic Strategies

The discovery of ABCC3 as a drug target and biomarker has led to a growing interest in the development of therapeutic strategies against various diseases.

One potential therapeutic strategy against cancer is the use of small molecules that can inhibit the function of ABCC3. This can be done by targeting the various functions of ABCC3, including its ability to regulate intracellular signaling pathways and to interact with various signaling molecules.

Another potential therapeutic strategy against neurodegenerative diseases is the use of antibodies that can target ABCC3 and inhibit its function in these diseases. This can be done by designing antibodies that specifically target ABCC3 and can be used to treat neurodegenerative diseases.

Conclusion

In conclusion, ABCC3 is a transmembrane protein that belongs to the family of ABC proteins. Its function in cellular signaling and its potential as a drug target and biomarker make it an attractive target for the development of new therapeutic strategies against various diseases. Further research is needed to fully understand the functions of ABCC3 and its potential as a therapeutic target.

Protein Name: ATP Binding Cassette Subfamily C Member 3

Functions: ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813)

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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