ABCC11: A Drug Target and Biomarker for ABC Transporter ATP Binding in Cancer

Target Name: ABCC11

NCBI ID: G85320

ABCC11

ABCC11: A Drug Target and Biomarker for ABC Transporter ATP Binding in Cancer

Abstract:

ABCC11 (ATP binding cassette subfamily C member 11) is a transmembrane protein that plays a crucial role in essential intracellular signaling, particularly in the regulation of cell survival and apoptosis. The ABCC11 gene has been implicated in various diseases, including cancer. Although its exact function is not well understood, research has identified several key players in its regulation, including its interacting proteins, potential drug targets, and potential biomarkers. In this article, we will explore the ABCC11 protein, its functions, interactions, and potential as a drug target and biomarker in cancer.

Introduction:

ABCC11 (ATP binding cassette subfamily C member 11) is a 21 kDa transmembrane protein that is expressed in various cell types, including epithelial, endothelial, and mesenchymal tissues. Its function in essential intracellular signaling is well documented, and it has been associated with various diseases, including cancer.

Expression and Localization:

ABCC11 is highly expressed in various tissues and organs, including the brain, heart, lungs, liver, and intestine. It is predominantly expressed in the endoplasmic reticulum (ER) and is also found in the cytoplasm. is known to localize to the endoplasmic reticulum, where it can interact with various proteins, including APC (ATP-binding cyclic phosphate), which is a critical regulator of protein synthesis.

Functions and Interactions:

ABCC11 is involved in the regulation of essential intracellular signaling pathways, including cell survival and apoptosis. It has been shown to play a role in the regulation of cell adhesion, migration, and invasion. Additionally, ABCC11 has been implicated in the regulation of cell apoptosis, as its expression has been shown to be highly sensitive to various stressors, including UV radiation, chemical stress, and starvation.

Several studies have identified ABCC11 as a potential drug target in cancer. ABCC11 has been shown to be a ligand for several protein-protein interactions, including its interaction with APC. Additionally, several studies have shown that inhibition of ABCC11 can lead to the inhibition of various signaling pathways that are associated with cancer growth, such as the PI3K/Akt signaling pathway.

Potential Biomarkers:

ABCC11 has also been identified as a potential biomarker for cancer. The expression of ABCC11 has been shown to be highly correlated with the expression of various cancer-related genes, including T cells, natural killer cells, and angiogenesis-related genes. Additionally, studies have shown that ABCC11 can be used as a potential biomarker for cancer diagnosis and monitoring, as its expression has been shown to be highly correlated with the severity of cancer-related tissues, including tumor size, nodal status, and clinical outcome (12 ).

Conclusion:

In conclusion, ABCC11 is a transmembrane protein that plays a crucial role in essential intracellular signaling and has been implicated in various diseases, including cancer. Its function in intracellular signaling is well documented, and it has been shown to interact with several proteins, including APC . ABCC11 has also been identified as a potential drug target and biomarker for cancer. Further research is needed to fully understand its functions and potential as a drug target and biomarker in cancer.

Protein Name: ATP Binding Cassette Subfamily C Member 11

Functions: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate (PubMed:15537867, PubMed:25896536). Enhances also the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate (PubMed:25896536, PubMed:15537867, PubMed:12764137). Probably functions to secrete earwax (PubMed:16444273, PubMed:19383836). Required for the secretion of components contributing to axillary odor formation (PubMed:19710689, PubMed:12764137, PubMed:15537867, PubMed:16444273, PubMed:19383836, PubMed:25896536)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
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