SMYD5: A Drug Target and Biomarker for Retinoic Acid Responsiveregulated Genes

Target Name: SMYD5

NCBI ID: G10322

SMYD5

SMYD5: A Drug Target and Biomarker for Retinoic Acid Responsiveregulated Genes

Abstract

SMYD5, a non-coding RNA molecule, has been identified as a potential drug target and biomarker for retinoic acid responsive genes. Retinoic acid is a crucial signaling molecule that regulates various cellular processes, including gene expression and development. SMYD5 has been shown to play a critical role in the regulation of retinoic acid signaling in various organisms, including humans. In this article, we will review the current research on SMYD5 and its potential as a drug target and biomarker for retinoic acid responsive genes.

Retinoic acid is a signaling molecule that plays a crucial role in the regulation of gene expression and development. It is a cytoplasmic protein that can enter the nucleus to interact with nuclear proteins and regulate their activity. Retinoic acid has been shown to regulate the expression of numerous genes, including those involved in cell adhesion, migration, and differentiation.

SMYD5 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for retinoic acid responsive genes. It is characterized by the presence of a unique open reading frame (ORF) that encodes a protein with a predicted localization to the nuclear envelope. ORFs are the functional units of RNA molecules that can be translated into proteins, and they are widely recognized as potential drug targets.

SMYD5 and Retinoic Acid Signaling

SMYD5 has been shown to play a critical role in the regulation of retinoic acid signaling in various organisms, including humans. Studies have shown that SMYD5 can interact with the cytoplasmic protein Retinoblastoma gene (RB) to regulate its activity. This interaction between SMYD5 and RB can lead to the inhibition of RB-mediated transcriptional activity, including the regulation of genes involved in cell adhesion and differentiation.

In addition to its interaction with RB, SMYD5 has also been shown to regulate the activity of other nuclear proteins involved in retinoic acid signaling, including the transcription factor p300 and the nuclear factor of activated T cells (NFAT). These interactions between SMYD5 and other nuclear proteins can lead to the regulation of gene expression and the development of cellular processes, including cell adhesion, migration, and differentiation.

SMYD5 as a Biomarker

SMYD5 has also been shown to serve as a potential biomarker for retinoic acid responsive genes. Studies have shown that the expression of SMYD5 is regulated by retinoic acid, and that its levels can be used as a measure of the activity of various genes involved in retinoic acid signaling. This allows for the potential use of SMYD5 as a biomarker for the diagnosis and treatment of diseases associated with retinoic acid signaling disorders.

SMYD5 as a Drug Target

SMYD5 has also been identified as a potential drug target for the treatment of various diseases associated with retinoic acid signaling disorders. Studies have shown that the inhibition of SMYD5 activity can lead to the activation of genes involved in cell adhesion, migration, and differentiation, and that this can be used as a therapeutic approach for the treatment of such diseases.

Conclusion

SMYD5 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for retinoic acid responsive genes. Its interaction with the cytoplasmic protein Retinoblastoma gene (RB) and the regulation of retinoic acid signaling by SMYD5 have been well-documented, and its potential as a biomarker and drug target make it an attractive candidate for further study. Further research is needed to fully understand the role of SMYD5 in the regulation of retinoic acid signaling and its potential as a therapeutic approach for the treatment of diseases associated with retinoic acid signaling disorders.

Protein Name: SMYD Family Member 5

Functions: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks (PubMed:28951459)

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