PP21: A Potential Drug Target and Biomarker (G10777)

Target Name: ARPP21

NCBI ID: G10777

ARPP21

PP21: A Potential Drug Target and Biomarker

Phosphoprotein 21 (PP21) is a protein that plays a crucial role in cell signaling pathways, including cell division, apoptosis, and metabolism. It is a key regulator of the cell cycle and has been implicated in various diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The regulation of PP21 by the CAMP-activated protein kinase (CAMK) is a well-established process that involves the formation of a protein-protein interaction network and the recruitment of various adaptor proteins.

In recent years, the study of PP21 has gained significant interest due to its potential as a drug target or biomarker. Several studies have identified potential binding sites on PP21 and have shown that inhibitors of PP21 can lead to therapeutic effects in various models of disease. However, the full potential of PP21 as a drug target or biomarker remains to be explored.

Drug Target Potential

PP21 has been identified as a potential drug target due to its involvement in various cellular processes that are crucial for disease development. Several studies have shown that PP21 is involved in cell proliferation, migration, and invasion, which are key factors in the development of cancer. In addition, PP21 has been shown to be involved in the regulation of cell apoptosis, which is a critical factor in the regulation of cell life cycle and has been implicated in various diseases, including neurodegenerative diseases.

One of the most promising aspects of PP21 as a drug target is its involvement in the regulation of cell signaling pathways. PP21 has been shown to play a role in the regulation of several signaling pathways, including the PI3K/Akt signaling pathway, the TGF-β signaling pathway, and the Wnt signaling pathway. In addition, PP21 has been shown to interact with several protein adaptors, including Myosin light chain kinase (MLCK), casein kinase 2 (CK2), and p16INK4a. These interactions may provide a target for small molecules that can inhibit PP21 activity and have the potential to therapeutic effects in disease.

Biomarker Potential

PP21 has also been identified as a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and metabolic disorders. The regulation of PP21 by the CAMK pathway is a well-established process that involves the formation of a protein-protein interaction network and the recruitment of various adaptor proteins. This process may provide a target for biomarkers that can be used to diagnose and monitor disease.

One of the most promising aspects of PP21 as a biomarker is its involvement in the regulation of cell apoptosis. PP21 has been shown to play a role in the regulation of cell apoptosis, which is a critical factor in the regulation of cell life cycle and has been implicated in various diseases, including neurodegenerative diseases. In addition, PP21 has been shown to interact with several protein adaptors, including Myosin light chain kinase (MLCK), casein kinase 2 (CK2), and p16INK4a. These interactions may provide a target for small molecules that can inhibit PP21 activity and have the potential to therapeutic effects in disease.

Conclusion

In conclusion, PP21 is a protein that has significant implications as a drug target or biomarker. Its involvement in the regulation of cell signaling pathways, including cell proliferation, migration, and invasion, as well as its involvement in the regulation of cell apoptosis, makes it a promising target for small molecules that can inhibit its activity. Further research is needed to fully explore the potential of PP21 as a drug target or biomarker and to develop effective therapies for the treatment of diseases associated with its regulation.

Protein Name: CAMP Regulated Phosphoprotein 21

Functions: Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons

The "ARPP21 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ARPP21 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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