ASF1B: A Protein Involved in Neurotransmission and Cellular Processes for The Survival of Neurons

Target Name: ASF1B

NCBI ID: G55723

ASF1B

ASF1B: A Protein Involved in Neurotransmission and Cellular Processes for The Survival of Neurons

ASF1B (hCIA-II) is a protein that is expressed in the brain and is known for its role in the development and progression of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The protein is derived from the human centromeric region of chromosome 12 and has been shown to interact with several other proteins, including tau and beta-amyloid.

ASF1B is a transmembrane protein that is expressed in the brain and has been shown to localize to various regions of the brain, including the prefrontal cortex, basal ganglia, and cerebellum. It is involved in the formation of neurotransmitter receptors, which are critical for the transmission of signals within the brain.

One of the most significant functions of ASF1B is its role in the formation of synapses, which are the structural elements that connect neurons in the brain. ASF1B is involved in the formation of the dendritic spikes that receive neurotransmitters from the axon and in the regulation of the strength of these spikes. This protein may be a drug target (or biomarker) for neurodegenerative diseases, as inhibition of ASF1B has been shown to improve neurotransmitter receptor function and reduce the progression of neurodegeneration.

In addition to its role in neurotransmission, ASF1B is also involved in the regulation of cellular processes that are critical for the survival and function of neurons. For example, ASF1B has been shown to play a role in the regulation of cell cycle progression and in the maintenance of neuronal stem cell populations.

ASF1B is also involved in the regulation of inflammation, which is a critical factor in the development and progression of neurodegenerative diseases. For example, ASF1B has been shown to play a role in the regulation of the immune response and in the production of pro-inflammatory cytokines.

ASF1B is a complex protein that is involved in a wide range of cellular processes that are critical for the survival and function of neurons. Its role in the formation of neurotransmitter receptors and its involvement in the regulation of cellular processes, including cell cycle progression, inflammation, and neurotransmission, make it an attractive target for drug development. Further research is needed to fully understand the role of ASF1B in neurodegenerative diseases and to develop effective treatments.

Protein Name: Anti-silencing Function 1B Histone Chaperone

Functions: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904)

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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