CIT: A Potential Drug Target and Biomarker for Citron Rho-Interacting Kinase (ISO Form 2)

Target Name: CIT

NCBI ID: G11113

Content of Review Report on CIT Target / Biomarker

CIT

CIT: A Potential Drug Target and Biomarker for Citron Rho-Interacting Kinase (ISO Form 2)

Citron Rho-interacting kinase (ISO Form 2) is a protein that plays a critical role in various cellular processes, including cell signaling, DNA replication, and metabolism. It is a member of the Rho GTPase family, which is known for their ability to regulate actin dynamics and cell-cell interactions. CIT functions as a GTPase, which means it can bind to GTP and regulate the subsequent protein interactions, leading to changes in cellular behavior. The ISO Form 2 is a unique isoform, as it has four active sites, including a GTP-binding site, a GTPase-activating site, and two GTP-binding sites.

CIT has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its role in these diseases has led to the search for potential drug targets and biomarkers. In this article, we will discuss the potential of CIT as a drug target and biomarker.

Potential Drug Target

CIT has been shown to play a role in various cellular processes that are crucial for human health. One of the primary targets of CIT is the regulation of actin dynamics. Actin is a protein that plays a critical role in cell-cell interactions, including cell migration, invasion, and signaling. CIT is involved in regulating the actin dynamics by regulating the activity of the microtubules, which are the fundamental structural elements that maintain actin integrity.

CIT has been shown to play a role in the regulation of microtubule dynamics in various cellular processes, including cell division, mitosis, and meiosis. It has been shown to regulate the assembly and disassembly of microtubules and to control the dynamics of tubulin, the protein that forms the microtubules. This regulation of microtubule dynamics is crucial for the proper functioning of cells, and alterations in microtubule dynamics have been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

CIT has also been shown to play a role in the regulation of cell signaling pathways. It has been shown to regulate the Notch signaling pathway, which is involved in cell proliferation, differentiation, and survival. CIT has also been shown to regulate the TGF-β signaling pathway, which is involved in cell growth, differentiation, and cancer development.

Potential Biomarker

CIT has also been shown to serve as a potential biomarker for various diseases. Its involvement in the regulation of actin dynamics and microtubule dynamics makes it an attractive target for biomarkers that can be used to diagnose and monitor diseases associated with these processes.

One of the primary biomarkers for CIT is its expression level. High levels of CIT expression have been shown to be associated with various diseases, including cancer, neurodegenerative diseases, and developmental disorders. This suggests that CIT may serve as a potential biomarker for these diseases.

Another biomarker for CIT is its activity level. CIT has been shown to play a role in the regulation of various cellular processes, including cell signaling, DNA replication, and metabolism. Its activity level can be used as a biomarker for various diseases associated with these processes.

Conclusion

In conclusion, CIT is a protein that has been shown to play a critical role in various cellular processes that are crucial for human health. Its involvement in the regulation of actin dynamics, microtubule dynamics, and cell signaling pathways makes it an attractive target for drug targets and biomarkers. The potential of CIT as a drug target and biomarker for various diseases makes it an important area of research for the future. Further studies are needed to fully understand the role of CIT in disease development and to develop effective treatments.

Protein Name: Citron Rho-interacting Serine/threonine Kinase

Functions: Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2

The "CIT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CIT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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