Clec4d: A Protein Associated with Disease Development (G338339)

Target Name: CLEC4D

NCBI ID: G338339

CLEC4D

Clec4d: A Protein Associated with Disease Development

CLEC4D (DC-associated C-type lectin 3) is a protein that is expressed in various tissues throughout the body, including the liver, spleen, and blood cells. It is a type of lectin, which is a protein that recognizes and binds to specific antigens on the surface of cells. Clec4d is particularly interesting because it is associated with the development and progression of many diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

One of the key functions of Clec4d is its ability to interact with the immune system. It is a key member of the major histocompatibility complex (MHC), which is a system that helps to present antigens to T cells. T cells are a critical part of the immune system, and they play a central role in fighting off infections and diseases. However, T cells can also cause damage to the body if they are not properly controlled. For example, in the case of cancer, T cells can be reprogrammed to become cancerous and contribute to the development and progression of the disease.

Clec4d is also involved in the regulation of inflammation. Many diseases, including cancer, involve chronic inflammation that is not properly controlled. Clec4d helps to regulate this inflammation by interacting with immune cells and controlling the production of pro-inflammatory molecules.

Another function of Clec4d is its role in cell signaling. It is a signaling molecule that can interact with a variety of different proteins, including tyrosine kinases. Tyrosine kinases are important for many different signaling pathways in the cell, and they play a key role in the development and progression of many diseases. Clec4d helps to regulate these signaling pathways by binding to the tyrosine kinase and preventing it from interacting with other proteins.

Clec4d is also associated with the development and progression of many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the symptoms of these diseases. Clec4d is thought to be involved in the production of these tangles by interacting with the neurofibrillary tangles and helping to promote their formation.

In addition to its involvement in the immune and inflammatory systems, Clec4d is also thought to be involved in the regulation of cell shape and movement. It is a protein that can interact with microtubules, which are the structural elements that give cells their shape and help them to move. This interaction is important for many different cellular processes, including cell division and transport.

Clec4d is also associated with the development and progression of many diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. These conditions are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles, which are thought to contribute to the symptoms of these diseases. Clec4d is thought to be involved in the production of these tangles by interacting with the neurofibrillary tangles and helping to promote their formation.

In conclusion, Clec4d is a protein that is associated with the development and progression of many diseases. Its functions include its ability to interact with the immune system, the regulation of inflammation, the regulation of cell signaling, and its role in the development and progression of many neurodegenerative diseases. As a result, Clec4d is thought to be a promising drug target for a variety of diseases. Further research is needed to fully understand the role of Clec4d in these diseases and to develop effective treatments.

Protein Name: C-type Lectin Domain Family 4 Member D

Functions: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi (PubMed:23602766, PubMed:23911656). The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (PubMed:23602766, PubMed:23911656). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (By similarity). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:23602766, PubMed:23911656). The heterodimer formed with CLEC6A is active against fungal infection (PubMed:23911656). Functions as an endocytic receptor (PubMed:14971047). May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (PubMed:14971047)

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•   general information;
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•   the target screening and validation;
•   expression level;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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