CLCN5: A Potential Drug Target and Biomarker (G1184)

Target Name: CLCN5

NCBI ID: G1184

CLCN5

CLCN5: A Potential Drug Target and Biomarker

CLCN5, or long chain chain truncated neuroleukine receptor subunit 5, is a protein that is expressed in various tissues of the brain, including neurons, glial cells, and microglia. It is a member of the neuroleukine receptor (NLR) family, which includes NLRP1, NLRP3, NLRC4, and others. CLCN5 is known for its role in the regulation of neuronal excitability and synaptic plasticity, and is considered a potential drug target in the field of neurological disorders.

The neuroleukine receptor family plays a crucial role in the regulation of neural circuits, including the transmission of signals between neurons and glial cells. NLR subunits are involved in the formation of a protein complex that is involved in the regulation of various cellular processes, including inflammation, neurotransmitter signaling, and cell survival. CLCN5 is one of the most well-studied NLR subunits, and its function in neural circuits is of great interest.

One of the key functions of CLCN5 is its role in the regulation of neuronal excitability. CLCN5 is involved in the regulation of the intracellular signaling pathway known as the Ca2+ signaling pathway. This pathway is involved in the regulation of many cellular processes, including muscle contractions, neurotransmitter release, and intracellular signaling. CLCN5 is known to play a role in the regulation of the Ca2+ signaling pathway in neurons, and studies have shown that it is involved in the regulation of neuronal excitability.

Another function of CLCN5 is its role in the regulation of synaptic plasticity. CLCN5 is involved in the regulation of the strengthening of neural synapses, which is a critical aspect of neural development and function. Synaptic plasticity is the ability of neural circuits to change in response to various stimuli, and is thought to be involved in the regulation of many cognitive functions, including learning and memory. CLCN5 is known to play a role in the regulation of synaptic plasticity, and studies have shown that it is involved in the regulation of the strengthening of neural synapses.

In addition to its role in the regulation of neuronal excitability and synaptic plasticity, CLCN5 is also involved in the regulation of inflammation. CLCN5 is known to play a role in the regulation of the production of pro-inflammatory cytokines, which are involved in the regulation of inflammation. This is thought to be an important function of CLCN5, as inflammation is involved in the development and progression of many neurological disorders.

Despite its involvement in a number of important cellular processes, CLCN5 is not well understood. There are currently few studies that have focused specifically on the function of CLCN5, and more research is needed to fully understand its role in neural circuits. However, the potential implications of CLCN5 as a drug target are significant. If CLCN5 is found to be involved in the regulation of neural circuits, it may be a promising target for the treatment of a variety of neurological disorders.

Protein Name: Chloride Voltage-gated Channel 5

Functions: Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:20466723). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable)

The "CLCN5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CLCN5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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