Target Name: CDC37
NCBI ID: G11140
Review Report on CDC37 Target / Biomarker Content of Review Report on CDC37 Target / Biomarker
CDC37
Other Name(s): Cell division cycle 37, HSP90 cochaperone | P50CDC37 | Hsp90 co-chaperone Cdc37 | CDC37_HUMAN | CDC37A | cell division cycle 37 homolog | Hsp90 co-chaperone Cdc37, N-terminally processed | CDC37 cell division cycle 37 homolog | p50Cdc37 | Hsp90 chaperone protein kinase-targeting subunit | CDC37 (cell division cycle 37, S. cerevisiae, homolog) | cell division cycle 37, HSP90 cochaperone | hsp90 chaperone protein kinase-targeting subunit

CDC37: A Promising Drug Target and Biomarker for Cancer Treatment

Cancer is one of the leading causes of morbidity and mortality worldwide, affecting millions of people. The standard treatment options for cancer have limited efficacy, leading to a growing interest in finding new approaches for cancer treatment. One of these approaches is the use of small molecules, such as drugs, to inhibit the cell division cycle (CDC).CDC is the process by which cells divide and grow, and it is critical for the growth and survival of cancer cells. In fact, many cancer drugs work by inhibiting the CDC to prevent cancer cells from multiplying. One of the proteins involved in the CDC is CDC37, which is a cochaperone that helps keep the CDC running smoothly. In this article, we will explore CDC37 as a drug target and biomarker for cancer treatment.

CDC37: The Cochaperone for the CDC

CDC37 is a protein that plays a critical role in the CDC. It is a 22-kDa protein that is found in various cell types, including bacteria, yeast, and eukaryotes. CDC37 helps to keep the CDC running smoothly by providing it with the necessary structural components.

One of the key functions of CDC37 is to bind to the protein p21, which is a G1-specific protein that is involved in the G1 phase of the cell division cycle. This interaction between CDC37 and p21 is critical for the proper functioning of the CDC.

CDC37 has also been shown to play a role in the regulation of cell growth and the determination of cell fate. In fact, studies have shown that CDC37 plays a key role in the regulation of cell cycle progression and that it is involved in the development of cancer.

CDC37 as a Drug Target

The use of drugs that inhibit the CDC to prevent cancer cells from multiplying is a promising approach to cancer treatment. One of the proteins involved in the CDC is CDC37, and research has shown that it is a potential drug target.

Studies have shown that inhibiting CDC37 can lead to the inhibition of cell growth and the inhibition of the CDC. This suggests that CDC37 may be an effective target for cancer treatment. In fact, several studies have shown that inhibitors of CDC37 have been effective in preclinical studies for the treatment of various cancers, including breast, ovarian, and colorectal cancers.

CDC37 as a Biomarker

In addition to its potential as a drug target, CDC37 has also been shown to be a potential biomarker for cancer. Studies have shown that the expression of CDC37 is significantly increased in various types of cancer, including breast, ovarian, and colorectal cancers. This suggests that CDC37 may be a useful biomarker for the diagnosis and prognosis of cancer.

CDC37 also has been shown to be a potential biomarker for the effectiveness of cancer treatments. For example, studies have shown that the expression of CDC37 is significantly decreased in the cells that have been treated with certain anti-cancer drugs, such as taxanes and vinca alkaloids. This suggests that CDC37 may be a useful biomarker for the assessment of the effectiveness of cancer treatments.

Conclusion

In conclusion, CDC37 is a protein that plays a critical role in the CDC and has been shown to be involved in the regulation of cell growth and the determination of cell fate. The use of drugs that inhibit the CDC to prevent cancer cells from multiplying is a promising approach to cancer treatment, and CDC37 has been shown to be a potential drug target and biomarker for cancer. Further research is needed to fully understand the role of CDC37 in cancer treatment and to develop effective treatments based on this protein.

Protein Name: Cell Division Cycle 37, HSP90 Cochaperone

Functions: Co-chaperone that binds to numerous kinases and promotes their interaction with the Hsp90 complex, resulting in stabilization and promotion of their activity (PubMed:8666233). Inhibits HSP90AA1 ATPase activity (PubMed:23569206)

The "CDC37 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CDC37 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

CDC37L1 | CDC37P1 | CDC40 | CDC42 | CDC42BPA | CDC42BPB | CDC42BPG | CDC42EP1 | CDC42EP2 | CDC42EP3 | CDC42EP4 | CDC42EP5 | CDC42SE1 | CDC42SE2 | CDC45 | CDC5L | CDC5L complex | CDC6 | CDC7 | CDC73 | CDCA2 | CDCA3 | CDCA4 | CDCA4P3 | CDCA5 | CDCA7 | CDCA7L | CDCA8 | CDCP1 | CDCP2 | CDH1 | CDH10 | CDH11 | CDH12 | CDH13 | CDH13-AS2 | CDH15 | CDH16 | CDH17 | CDH18 | CDH19 | CDH2 | CDH20 | CDH22 | CDH23 | CDH24 | CDH26 | CDH3 | CDH4 | CDH5 | CDH6 | CDH7 | CDH8 | CDH9 | CDHR1 | CDHR18P | CDHR2 | CDHR3 | CDHR4 | CDHR5 | CDIN1 | CDIP1 | CDIPT | CDIPTOSP | CDK1 | CDK10 | CDK11A | CDK11B | CDK12 | CDK13 | CDK14 | CDK15 | CDK16 | CDK17 | CDK18 | CDK19 | CDK2 | CDK20 | CDK2AP1 | CDK2AP2 | CDK2AP2P2 | CDK2AP2P3 | CDK3 | CDK4 | CDK5 | CDK5R1 | CDK5R2 | CDK5RAP1 | CDK5RAP2 | CDK5RAP3 | CDK6 | CDK6-AS1 | CDK7 | CDK8 | CDK9 | CDKAL1 | CDKL1 | CDKL2 | CDKL3 | CDKL4