SERTAD3: Potential Drug Target for Alzheimer's and Other Disorders

Target Name: SERTAD3

NCBI ID: G29946

SERTAD3

SERTAD3: Potential Drug Target for Alzheimer's and Other Disorders

SERTAD3 (SERTAD3 variant 1) is a protein that is expressed in the brain and plays a role in the development and progression of several neurological disorders, including Alzheimer's disease. The protein is known for its ability to interact with dopamine, a chemical that is involved in the transmission of signals in the brain.

Research has shown that SERTAD3 is involved in the formation of beta-amyloid plaques, a hallmark of Alzheimer's disease, as well as the progression of neurodegeneration in the brain. Studies have also shown that inhibiting SERTAD3 can lead to reduced levels of beta-amyloid plaque formation and improved cognitive function in individuals with Alzheimer's disease.

In addition to its involvement in the development and progression of Alzheimer's disease, SERTAD3 has also been shown to be involved in a variety of other neurological disorders, including Parkinson's disease, Huntington's disease, and multiple sclerosis.

SERTAD3 is a member of the superfamily of transmembrane proteins, which means that it is a protein that is located on the surface of the cell and spans the entire membrane. It is made up of four transmembrane domains and a cytoplasmic tail. The cytoplasmic tail is important for the protein's ability to interact with other proteins and molecules within the cell.

SERTAD3 is expressed in a variety of tissues and cells, including the brain, heart, and pancreas. It is most highly expressed in the brain, where it is involved in the development and progression of beta-amyloid plaques and neurodegeneration.

In addition to its involvement in the development and progression of Alzheimer's disease, SERTAD3 is also thought to be involved in the regulation of other proteins and processes that are important for brain health. For example, studies have shown that SERTAD3 can interact with the protein synapse, which is a structure that is responsible for the exchange of information between neurons. This interaction may be important for the regulation of neurotransmitter release and the development of neurodegeneration.

Another study has shown that SERTAD3 can interact with the protein Parkin, which is involved in the regulation of mitochondrial function. This interaction may be important for the regulation of energy metabolism and the development of neurodegeneration.

SERTAD3 is also thought to be involved in the regulation of the immune response. Studies have shown that SERTAD3 can interact with the protein PDGF-RB, which is involved in the regulation of cell growth and differentiation. This interaction may be important for the regulation of immune cell function and the development of autoimmune disorders.

In conclusion, SERTAD3 is a protein that is involved in a variety of processes that are important for brain health. Studies have shown that SERTAD3 is involved in the development and progression of beta-amyloid plaque formation, as well as the regulation of other proteins and processes that are important for brain health. As a result, SERTAD3 is a potential drug target and biomarker for a variety of neurological disorders, including Alzheimer's disease. Further research is needed to fully understand the role of SERTAD3 in brain health and to develop effective treatments for these disorders.

Protein Name: SERTA Domain Containing 3

Functions: Antiviral interferon-stimulated protein that plays a role in innate immunity and in the suppression of viruses through different mechanisms (PubMed:33147462, PubMed:36594413). Plays a role in the late phase response of TLR-induced immune effector expression (By similarity). During influenza infection, interacts with PB2, PB1, and PA to disrupt the formation of the viral RdRp complex (PubMed:33147462). Inhibits zika virus by interacting with the capsid protein in the nucleolus and reducing its abundance through proteasomal degradation (PubMed:36594413). Strong transcriptional coactivator (PubMed:10982866)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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