Target Name: RNF19B
NCBI ID: G127544
Review Report on RNF19B Target / Biomarker Content of Review Report on RNF19B Target / Biomarker
RNF19B
Other Name(s): E3 ubiquitin-protein ligase RNF19B (isoform a) | Natural killer lytic-associated molecule | Ring finger protein 19B, transcript variant 1 | IBR domain containing 3 | NKLAM | RING finger protein 19B | IBRDC3 | FLJ90005 | IBR domain-containing protein 3 | natural killer lytic-associated molecule | RN19B_HUMAN | RNF19B variant 1 | E3 ubiquitin-protein ligase RNF19B | ring finger protein 19B

Unlocking the Potential of RNF19B as a Drug Target and Biomarker

Introduction

Rare nuclear factor (RNF) proteins are a family of transducing RNA-binding proteins, which play a crucial role in various cellular processes, including DNA replication, transcription, and DNA damage repair. Among the RFP, RNA-binding protein 19B (RNF19B) is A striking protein, it is a representative member of the E3 ubiquitin-protein enzyme family. RNF19B plays a key role in the cell cycle, DNA replication and apoptosis and is therefore considered a potential drug target and biomarker. This article will discuss RNF19B from multiple perspectives such as molecular biology, pharmacology and clinical application, with a view to providing useful inspiration for research in related fields.

molecular biology perspective

The Chinese name of RNF19B is RNA-binding protein 19B, and its encoding gene is NUP54, which is a member of the E3 ubiquitinase family. Members of this family are responsible for binding ubiquitin molecules within cells and thus participating in a series of biological processes. The functions of RNF19B are mainly reflected in life processes such as cell cycle, DNA replication and apoptosis.

During the cell cycle, RNF19B is involved in mitotic progression. It binds to spindle tubulin and aids in the assembly and separation of spindle fibers. In addition, RNF19B also binds to nucleolar tubulin and affects the stability of the nucleolar structure. These findings indicate that RNF19B plays an important role in the process of cell mitosis and provide new ideas for in-depth study of cell cycle regulatory mechanisms.

During DNA replication, RNF19B acts as a substrate for DNA polymerase 1 (DNAP1). DNAP1 is an indispensable protein in the DNA replication process. It binds DNA templates and generates new DNA strands during the polymerization process. The binding effect of RNF19B enables DNAP1 to bind DNA templates more efficiently, thereby improving DNA replication efficiency.

During the process of apoptosis, RNF19B interacts with a series of apoptosis-related proteins and participates in intracellular apoptosis signaling. Apoptosis is a normal life process of organisms. For multicellular organisms, apoptosis plays an important role in removing damaged cells and maintaining tissue homeostasis. By studying the role of RNF19B in the process of apoptosis, new targets can be provided for the development of anti-apoptotic drugs.

pharmacological significance

Pharmacological research on RNF19B mainly focuses on two aspects: drug design and efficacy evaluation.

1. Drug Design

Drug design is the process of selecting molecular targets and designing drugs for specific diseases or targets. For RNF19B, a potential drug target, researchers can try to design a series of more specific drug molecules to treat diseases by interfering with the function of RNF19B. For example, by blocking the activity of RNF19B, key life processes such as cell cycle and DNA replication can be inhibited, thereby achieving anti-tumor, anti-inflammatory and other purposes.

2. Drug efficacy evaluation

Drug efficacy evaluation is to evaluate the effect of drugs on target targets to determine the therapeutic effect of drugs on diseases. For the drug target RNF19B, drug efficacy can be evaluated through a variety of methods, such as cell level, animal models and clinical trials.

(1) Cell level

Cell-level studies are an important method to evaluate the impact of drugs on their intended targets. Through techniques such as flow cytometry, immunofluorescence staining, and gene sequencing, the effects of drugs on biological processes such as cell cycle and DNA replication can be detected. For example, researchers can observe the effect of drugs on RNF19B expression levels to evaluate the inhibitory effect of drugs on RNF19B.

(2) Animal model

Animal models are experimental animals that simulate physiological processes in the body. By observing the efficacy of drugs in animals, the therapeutic effect of drugs on diseases can be evaluated.

Protein Name: Ring Finger Protein 19B

Functions: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036)

The "RNF19B Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF19B comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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