Eph Receptor A4 and Its Association with Diseases (G2043)

Target Name: EPHA4

NCBI ID: G2043

EPHA4

Eph Receptor A4 and Its Association with Diseases

The Eph receptor A4 (EPHA4) is a protein that plays a crucial role in the development and maintenance of tissues, including the nervous system and blood vessels. It is a member of the Eph receptor tyrosine kinase family, which is a family of transmembrane proteins that mediate the delivery of growth factors and other signaling molecules to cells. The Eph receptor A4 gene has four exons, and it encodes a protein that is expressed in many tissues throughout the body.

The Eph receptor A4 protein is involved in several cellular processes, including cell proliferation, differentiation, and survival. It is a key regulator of the Wnt signaling pathway, which is a well-established pathway that regulates cell growth and development. The Wnt signaling pathway is involved in the development and maintenance of tissues, including the nervous system and blood vessels, and it is a crucial factor in the development of many diseases, including cancer and neurodegenerative diseases.

EPHA4 is also involved in the FGF signaling pathway, which is a signaling pathway that is involved in cell proliferation and differentiation. The FGF signaling pathway is involved in the development and maintenance of tissues, including the nervous system and blood vessels, and it is a crucial factor in the development of many diseases, including cancer and neurodegenerative diseases.

Diseases associated with Eph receptor A4

Eph receptor A4 is involved in several cellular processes that are important for human health and the development of many diseases. It is a key regulator of the Wnt and FGF signaling pathways, which are involved in the development and maintenance of tissues, including the nervous system and blood vessels. As a result, diseases that are associated with changes in these signaling pathways, including the levels of Eph receptor A4, can have a significant impact on human health and the development of many diseases.

One of the well-established diseases associated with changes in the Eph receptor A4 signaling pathway is cancer. The Eph receptor A4 is involved in the development and maintenance of tissues, and it is a key regulator of the Wnt and FGF signaling pathways. As a result, changes in the levels of Eph receptor A4 can have a significant impact on the development and progression of cancer. For example, studies have shown that high levels of Eph receptor A4 are associated with the development of many types of cancer, including breast, ovarian, and prostate cancers.

Another disease associated with changes in the Eph receptor A4 signaling pathway is neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The Eph receptor A4 is involved in the development and maintenance of tissues, including the nervous system, and it is a key regulator of the Wnt and FGF signaling pathways. As a result, changes in the levels of Eph receptor A4 can have a significant impact on the development and progression of neurodegenerative diseases. For example, studies have shown that low levels of Eph receptor A4 are associated with the development of neurodegenerative diseases, while high levels of Eph receptor A4 are associated with the progression of these diseases.

The role of Eph receptor A4 in diseases

Eph receptor A4 is involved in several cellular processes that are important for human health and the development of many diseases. It is a key regulator of the Wnt and FGF signaling pathways, which are involved in the development and maintenance of tissues, including the nervous system and blood vessels. As a result, diseases that are associated with changes in these signaling pathways, including the levels of Eph receptor A4, can have a significant impact on human health and the development of many diseases.

One of the well-established diseases associated with changes in the Eph receptor A4 signaling pathway is cancer. The Eph receptor A4 is involved in the development and maintenance of tissues, and it is a key regulator of the Wnt and FGF signaling pathways. As a result, changes in the levels of Eph receptor A4 can have a significant impact on the development and progression of cancer. For example, studies have shown that high levels of Eph receptor A4 are associated with the development of many types of cancer, including breast, ovarian, and prostate cancers.

Another disease associated with changes in the Eph receptor A4 signaling pathway is neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. The Eph receptor A4 is involved in the development and maintenance of tissues, including the nervous system, and it is a key regulator of the Wnt and FGF signaling pathways. As a result, changes in the levels of Eph receptor A4 can have a significant impact on the development and progression of neurodegenerative diseases. For example, studies have shown that low levels of Eph receptor A4 are associated with the development of neurodegenerative diseases, while high levels of Eph receptor A4 are associated with the progression of these diseases.

Conclusion

Eph receptor A4 is a protein that plays a crucial role in the development and maintenance of tissues, including the nervous system and blood vessels. It is a member of the Eph receptor tyrosine kinase family, and it is involved in several cellular processes, including cell proliferation, differentiation, and survival. Eph receptor A4 is also involved in the Wnt and FGF signaling pathways, and it is a key regulator of the development and maintenance of tissues. The levels of Eph receptor A4 have been associated with the development and progression of many diseases, including cancer and neurodegenerative diseases. Therefore, Eph receptor A4 is a potential drug target and biomarker for the treatment of these diseases.

Protein Name: EPH Receptor A4

Functions: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis. In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation. Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (By similarity). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (By similarity)

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