EPHB2: A Protein Regulating Tissue and Organ Development (G2048)

Target Name: EPHB2

NCBI ID: G2048

EPHB2

EPHB2: A Protein Regulating Tissue and Organ Development

EPHB2 (Developmentally-regulated Eph-related tyrosine kinase) is a protein that plays a crucial role in the development and maintenance of tissues and organs, particularly the retina. It is a member of the Eph receptor tyrosine kinase family, which is a subfamily of the tyrosine kinase receptor family. EPHB2 is involved in the regulation of cell proliferation, differentiation, and survival, and is a potential drug target or biomarker for several diseases.

The Eph receptor tyrosine kinase family is a transmembrane protein that is characterized by the presence of an extracellular domain, a transmembrane domain, and an intracellular domain. The EPHB2 protein is similar to other members of the Eph receptor tyrosine kinase family in that it contains a catalytic tyrosine kinase domain, a nucleotide-binding domain, and a cytoplasmic domain.

The EPHB2 protein is involved in the development and maintenance of tissues and organs, particularly the retina. The retina is a sensitive organ that is responsible for visualizing the world around us. It is composed of photoreceptor cells that are responsible for transmitting visual information to the brain. The retina is also home to the EPHB2 protein, which plays a role in its development and maintenance.

One of the functions of the EPHB2 protein is to regulate cell proliferation and differentiation. The EPHB2 protein is involved in the regulation of cell growth and the establishment of cell-cell contacts. It is also involved in the regulation of cell survival and the regulation of cell angiogenesis. These functions are essential for the development and maintenance of tissues and organs, including the retina.

The EPHB2 protein is also involved in the regulation of cell signaling pathways. It is a negative regulator of the RGY1/FAK-associated signaling pathway, which is involved in cell survival and angiogenesis. The RGY1/FAK-associated signaling pathway is a critical pathway that is involved in the regulation of cell survival and the establishment of cell-cell contacts. The EPHB2 protein helps to regulate the activity of this pathway, which is essential for the development and maintenance of tissues and organs.

In addition to its functions in cell proliferation and differentiation, the EPHB2 protein is also involved in the regulation of cell signaling pathways. It is a negative regulator of the TGGF-尾 pathway, which is involved in cell growth, angiogenesis, and the regulation of cell signaling pathways. The TGGF-尾 pathway is a critical pathway that is involved in the regulation of cell growth, angiogenesis, and the development of tissues and organs. The EPHB2 protein helps to regulate the activity of this pathway, which is essential for the development and maintenance of tissues and organs.

The EPHB2 protein is also involved in the regulation of cell-cell interactions. It is a critical regulator of the tight junction, which is a structure that helps to maintain the integrity of the retina. The tight junction is responsible for the regulation of the flow of nutrients and waste products into and out of cells, which is essential for the survival and health of the retina. The EPHB2 protein helps to regulate the tight junction, which is essential for the development and maintenance of the retina.

In conclusion, EPHB2 (Developmentally-regulated Eph-related tyrosine kinase) is a protein that plays a crucial role in the development and maintenance of tissues and organs, particularly the retina. It is a member of the Eph receptor tyrosine kinase family and is involved in the regulation of cell proliferation, differentiation, survival, and cell-cell interactions. The EPHB2 protein is a potential drug target or biomarker for several diseases, including cancer, neurodegenerative diseases, and developmental disorders. Further research is needed to fully understand the role of the EPHB2 protein in

Protein Name: EPH Receptor B2

Functions: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (PubMed:30213874)

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