XRN2: A Potential Drug Target for Cell Death and Proliferation

Target Name: XRN2

NCBI ID: G22803

XRN2

XRN2: A Potential Drug Target for Cell Death and Proliferation

XRN2 (Dhm1-like protein (mouse homolog)) is a protein that is expressed in a variety of tissues throughout the body, including the brain, spleen, and Peyer's patches in the intestine. It is characterized by its ability to interact with the protein Dhm1, which is also known as XRN2.

The XRN2 protein is of interest as a potential drug target or biomarker due to its involvement in a variety of physiological processes. One of the most significant functions of XRN2 is its role in the regulation of cell death, which is a critical process that helps maintain tissue homeostasis and ensure the integrity of various physiological processes.

XRN2 has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. This is important for the development and maintenance of tissues and organs, as well as for maintaining the overall health of the body.

In addition to its role in cell apoptosis, XRN2 has also been shown to be involved in the regulation of cell proliferation. This is important for the growth and development of tissues, as well as for maintaining the integrity of various physiological processes.

The interaction between XRN2 and Dhm1 is also of interest as a potential drug target. XRN2 has been shown to be able to interact with Dhm1 and to play a role in the regulation of Dhm1 function. This suggests that targeting XRN2 may be a useful way to modulate the activity of Dhm1 and potentially lead to therapeutic benefits.

In conclusion, XRN2 is a protein that is of interest as a potential drug target or biomarker due to its involvement in the regulation of cell death and proliferation. Its interaction with Dhm1 suggests that targeting XRN2 may be a useful way to modulate the activity of Dhm1 and potentially lead to therapeutic benefits. Further research is needed to fully understand the role of XRN2 in various physiological processes and to determine the most effective method for targeting it.

Protein Name: 5'-3' Exoribonuclease 2

Functions: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224)

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•   general information;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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