A closer look at YBX1 (MGC110976): A potential drug target and biomarker

Target Name: YBX1

NCBI ID: G4904

YBX1

A closer look at YBX1 (MGC110976): A potential drug target and biomarker

Introduction

YBX1 (MGC110976) is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer. Its unique structure and various bioactive interactions with other proteins make it an intriguing candidate for further research. In this article, we will provide a comprehensive overview of YBX1, including its structure, function, and potential as a drug target and biomarker.

Structure and function

YBX1 is a protein that belongs to the YBX family, which is known for its role in various cellular processes, including cell signaling, DNA replication, and repair. The YBX family has also been implicated in several diseases, including cancer. YBX1 is a 21 -kDa protein that consists of 195 amino acid residues.

One of the most striking features of YBX1 is its unique structure. It has a characteristic \"spoon\"-like shape, which is reminiscent of a sugar molecule. This shape allows YBX1 to interact with other proteins in a variety of ways, including through its conserved basic amino acid residues and its ability to form inclusion complexes with a variety of protein partners.

YBX1's structure also allows it to interact with DNA. In fact, studies have shown that YBX1 can form inclusion complexes with DNA, which can lead to changes in gene expression levels. This interaction between YBX1 and DNA makes it a potentially interesting drug target for diseases that are characterized by disruptions in DNA replication and repair, such as cancer.

Potential as a drug target

The potential of YBX1 as a drug target is based on several factors. Firstly, its unique structure, which allows it to interact with other proteins and DNA, makes it an attractive target for small molecules that can modulate its activity. Secondly, its involvement in Various cellular processes, including cell signaling and DNA replication, makes it a potential target for drugs that are effective in these processes.

Several studies have shown that YBX1 can be targeted by small molecules, including inhibitors of DNA replication and transcription. For example, one study published in the journal Nature Communications used a high-throughput screening approach to identify small molecules that could interact with YBX1 and modulate its activity. The results showed that several compounds were able to inhibit YBX1's activity, suggesting that they may be useful as potential drug candidates against cancer.

In addition to its potential as a drug target, YBX1 is also a potential biomarker for cancer. Its involvement in DNA replication and repair makes it an attractive target for biomarkers that can be used to diagnose or predict the severity of cancer. For example, one study published in the journal Cancer Research used YBX1 as a biomarker to predict the survival of patients with colorectal cancer. The results showed that higher levels of YBX1 were associated with poor prognosis in patients with colorectal cancer.

Potential as a biomarker

YBX1's potential as a biomarker for cancer is based on its involvement in DNA replication and repair. As discussed above, several studies have shown that YBX1 can form inclusion complexes with DNA, which can lead to changes in gene expression levels. This interaction between YBX1 and DNA makes it an attractive target for biomarkers that can be used to diagnose or predict the severity of cancer.

In addition to its potential as a biomarker, YBX1 is also a potential drug target for cancer. As discussed above, several studies have shown that YBX1 can be targeted by small molecules that can modulate its activity. The results of these studies suggest that YBX1 may be an attractive target for

Protein Name: Y-box Binding Protein 1

Functions: DNA- and RNA-binding protein involved in various processes, such as translational repression, RNA stabilization, mRNA splicing, DNA repair and transcription regulation (PubMed:8188694, PubMed:10817758, PubMed:11698476, PubMed:14718551, PubMed:18809583, PubMed:31358969). Predominantly acts as a RNA-binding protein: binds preferentially to the 5'-[CU]CUGCG-3' RNA motif and specifically recognizes mRNA transcripts modified by C5-methylcytosine (m5C) (PubMed:19561594, PubMed:31358969). Promotes mRNA stabilization: acts by binding to m5C-containing mRNAs and recruiting the mRNA stability maintainer ELAVL1, thereby preventing mRNA decay (PubMed:10817758, PubMed:11698476, PubMed:31358969). Component of the CRD-mediated complex that promotes MYC mRNA stability (PubMed:19029303). Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Plays a key role in RNA composition of extracellular exosomes by defining the sorting of small non-coding RNAs, such as tRNAs, Y RNAs, Vault RNAs and miRNAs (PubMed:27559612, PubMed:29073095). Probably sorts RNAs in exosomes by recognizing and binding C5-methylcytosine (m5C)-containing RNAs (PubMed:28341602, PubMed:29073095). Acts as a key effector of epidermal progenitors by preventing epidermal progenitor senescence: acts by regulating the translation of a senescence-associated subset of cytokine mRNAs, possibly by binding to m5C-containing mRNAs (PubMed:29712925). Also involved in pre-mRNA alternative splicing regulation: binds to splice sites in pre-mRNA and regulates splice site selection (PubMed:12604611). Also able to bind DNA: regulates transcription of the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7' (PubMed:18809583). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes (PubMed:8188694, PubMed:18809583). Promotes separation of DNA strands that contain mismatches or are modified by cisplatin (PubMed:14718551). Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA, suggesting a role in DNA repair (PubMed:14718551). The secreted form acts as an extracellular mitogen and stimulates cell migration and proliferation (PubMed:19483673)

The "YBX1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about YBX1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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