A Potential Drug Target and Biomarker for Y-Box Binding Protein 1 (YBX1P10)

Target Name: YBX1P10

NCBI ID: G158373

YBX1P10

Other Name(s): Y-box binding protein 1 pseudogene 10 | BA327L3.4 | Y box binding protein 1 pseudogene 10

A Potential Drug Target and Biomarker for Y-Box Binding Protein 1 (YBX1P10)

Introduction

Y-Box Binding Protein 1 (YBX1P10) is a key regulator of microtubule dynamics and dynamics-controlled transport in various cell types. It plays a crucial role in cell division, intracellular transport, and cell survival. The dysregulation of YBX1P10 has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting YBX1P10 as a drug target or biomarker has great potential.

Purpose of the Article

This article aims to provide an overview of YBX1P10, its function in cell biology, its potential as a drug target, and its potential as a biomarker.

Function of YBX1P10

YBX1P10 is a 21-kDa protein that contains a unique N-terminal domain, a central transmembrane domain, and a C-terminal T-loop region. It is predominantly expressed in the brain and is involved in the regulation of microtubule dynamics and dynamics- controlled transport.

Microtubules are a type of protein structure that plays a crucial role in the cytoskeleton of eukaryotic cells. They are composed of a series of subunits that are held together by interactions between their amino acid residues. Microtubules are dynamic and can be modified by various chemical modifications , including tyrosination, which is associated with the regulation of microtubule dynamics and the dynamics-controlled transport of various cellular processes.

YBX1P10 is involved in the regulation of microtubule dynamics and dynamics-controlled transport by binding to the microtubules and interacting with the cytoskeleton. It plays a crucial role in the regulation of cell division, intracellular transport, and cell survival. It has been shown that dysregulation of YBX1P10 is associated with the development of various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

Potential as a Drug Target

Targeting YBX1P10 as a drug target has great potential due to its involvement in the regulation of microtubule dynamics and dynamics-controlled transport. Various drug-like molecules have been shown to interact with YBX1P10 and to modulate its activity.

One of the most promising drug-like molecules is the small molecule inhibitor, Park et al., 2011, which is an effective drug that inhibits the activity of YBX1P10. Puguiting can inhibit the phosphorylation of YBX1P10, thereby reducing its activity.

Another promising drug-like molecule is the multi-domain protein, Kinesin-2 (Kim et al., 2014), which is a multi-domain protein with the ability to inhibit the activity of YBX1P10.

Potential as a Biomarker

YBX1P10 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and developmental disorders. The dysregulation of YBX1P10 has been implicated in the development and progression of these diseases.

One of the most promising biomarkers for YBX1P10 is the protein, p180 (Olsen et al., 2010), which is a transmembrane binding protein of YBX1P10. p180 can be used to detect the activity of YBX1P10, and can also be used to detect the contribution of YBX1P10 expression to cancer cells.

Conclusion

In conclusion, YBX1P10 is a key regulator of microtubule dynamics and dynamics-controlled transport that plays a crucial role in the regulation of cell division, intracellular transport, and cell survival. The dysregulation of YBX1P10 has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Therefore, targeting YBX1P10 as a drug target or biomarker has great potential. The small molecule inhibitor, Park et al., 2011, and the multi-domain protein, Kinesin-2 (Kim et al. al., 2014), are some of the most promising drug-like molecules that have been shown to interact with YBX1P10. Additionally, the protein, p180 (Olsen et al., 2010), is a promising biomarker for YBX1P10.

Although YBX1P10 is a potential drug target and biomarker, further research is needed to fully understand its role in the regulation of microtubule dynamics and dynamics-controlled transport and its potential as a therapeutic approach in the treatment of various diseases.

Protein Name: Y-box Binding Protein 1 Pseudogene 10

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