DCAF8 and GAN2: Regulators of Neurotransmission and Cellular Signaling

Target Name: DCAF8

NCBI ID: G50717

DCAF8

DCAF8 and GAN2: Regulators of Neurotransmission and Cellular Signaling

DCAF8 (GAN2) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the G-protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane and intracellular proteins that play a key role in cellular signaling.

GPCR signaling pathways involve the interaction between agonist and receptor proteins, which leads to the production of a downstream signaling molecule, called a ligand-induced signaling molecule (LISM), which then activates downstream signaling pathways. DCAF8 is involved in several of these signaling pathways , including the regulation of ion channels, neurotransmitter signaling, and cell survival.

One of the unique features of DCAF8 is its role in the regulation of neurotransmitter signaling. DCAF8 has been shown to play a critical role in the regulation of dopamine (D2) receptor function, which is involved in motor movement, emotion, and other physiological processes . DCAF8 has been shown to regulate the trafficking of dopamine receptors to the endoplasmic reticulum, which is the site of their synthesis and degradation. This regulation is critical for the normal function of dopamine receptors and is a potential drug target for the treatment of various neurological disorders. and psychiatric disorders.

In addition to its role in neurotransmitter signaling, DCAF8 is also involved in the regulation of cell survival. DCAF8 has been shown to play a critical role in the regulation of cell apoptosis, which is the process by which cells undergo programmed cell death. DCAF8 has has been shown to promote the clearance of damaged or dysfunctional cells, which is a critical function for maintaining tissue homeostasis and repair.

DCAF8 is also involved in the regulation of ion channels, which are critical for the proper functioning of many physiological processes, including muscle and nerve function. DCAF8 has been shown to regulate the trafficking of ion channels to the endoplasmic reticulum, which is the site of their synthesis and degradation. This regulation is critical for the normal function of ion channels and is a potential drug target for the treatment of various neurological and psychiatric disorders.

GAN2 is a family of GPCR proteins that include DCAF8. GAN2 proteins are involved in a wide range of physiological processes, including sensory perception, neurotransmission, and cellular signaling. GAN2 proteins are characterized by their ability to interact with agonist and receptor proteins, leading to the production of a downstream signaling molecule (LISM) that activates downstream signaling pathways.

GAN2 signaling pathways involve the interaction between agonist and receptor proteins, which leads to the production of a downstream signaling molecule (LISM), which then activates downstream signaling pathways. GAN2 proteins have been shown to play a critical role in the regulation of a wide range of physiological processes, including sensory perception, neurotransmission, and cellular signaling.

One of the unique features of GAN2 is its role in the regulation of sensory perception. GAN2 proteins have been shown to play a critical role in the regulation of the sense of touch, as well as the perception of pain, anxiety, and other sensory stimuli . GAN2 proteins have also been shown to regulate the trafficking of sensory receptors to the endoplasmic reticulum, which is the site of their synthesis and degradation. This regulation is critical for the normal function of sensory receptors and is a potential drug target for the treatment of various neurological and psychiatric disorders.

In addition to its role in sensory perception, GAN2 is also involved in the regulation of neurotransmission. GAN2 proteins have been shown to play a critical role in the regulation of neurotransmitter release from neurons, which is critical for the transmission of signals between neurons. GAN2 proteins have also been shown to regulate the trafficking of neurotransmitter

Protein Name: DDB1 And CUL4 Associated Factor 8

Functions: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

The "DCAF8 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DCAF8 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets