DCAF15: A Potential Drug Target for Cancer and Neurodegenerative Diseases

Target Name: DCAF15

NCBI ID: G90379

DCAF15

Other Name(s): DDB1 and CUL4 associated factor 15 | DDB1- and CUL4-associated factor 15 | C19orf72

DCAF15: A Potential Drug Target for Cancer and Neurodegenerative Diseases

DCAF15 (DDB1 and CUL4 associated factor 15) is a protein that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for researchers to study, and its potential as a drug has led to a significant amount of research and development in this field.

Structure and Function

DCAF15 is a protein that consists of 254 amino acids. It has a molecular weight of 31 kDa and a calculated pI of 5.9. DCAF15 is localized to the endoplasmic reticulum (ER) and is predominantly expressed in the brain and spinal cord. It is also found in other tissues, including the liver, heart, and kidneys. DCAF15 is a scaffold protein that plays a role in the organization and stability of the endoplasmic reticulum. It is composed of two distinct domains: an N-terminal transmembrane domain and a C -terminal cytoplasmic domain.

The N-terminal transmembrane domain of DCAF15 consists of a single amino acid residue at position 14. This domain is responsible for the protein's ability to interact with various signaling molecules, including tyrosine, which is a known substrate for the protein. Cytoplasmic domain of DCAF15 is responsible for the protein's ability to interact with the endoplasmic reticulum. This domain is composed of a series of conserved amino acids that are involved in the formation of a conserved oligomeric region (OR) that is involved in protein-protein interactions.

DCAF15 is a key regulator of the endoplasmic reticulum and is involved in the transport of various proteins to the ER. It has been shown to play a role in the regulation of cellular signaling pathways, including the TGF-β pathway. TGF-β is a well-known signaling pathway that is involved in the regulation of cell growth, differentiation, and survival. DCAF15 has been shown to play a role in the regulation of TGF-β signaling by affecting the stability of the endoplasmic reticulum and the levels of TGF- 尾 in the cell.

In addition to its role in TGF-β signaling, DCAF15 has also been shown to play a role in the regulation of other signaling pathways, including the Wnt signaling pathway. Wnt is a signaling pathway that is involved in the regulation of cell growth, development , and survival. DCAF15 has been shown to play a role in the regulation of Wnt signaling by affecting the stability of the endoplasmic reticulum and the levels of Wnt in the cell.

DCAF15 has also been shown to play a role in the regulation of cellular stress responses. Stresses, such as those caused by environmental toxins or oxidative stress, can have detrimental effects on cellular health. DCAF15 has also been shown to play a role in the regulation of cellular stress responses by affecting the levels of stress-responsive signaling pathways, including the ER stress response pathway.

DCAF15 is also involved in the regulation of cellular apoptosis, which is the process by which cells die when they have reached a certain level of stress or damage. DCAF15 has been shown to play a role in the regulation of cellular apoptosis by affecting the levels of Apoptosis-related signaling pathways, including the Bcl-2 pathway. Bcl-2 is a well-known gene that is involved in the regulation of

Protein Name: DDB1 And CUL4 Associated Factor 15

Functions: Substrate-recognition component of the DCX(DCAF15) complex, a cullin-4-RING E3 ubiquitin-protein ligase complex that mediates ubiquitination and degradation of target proteins (PubMed:16949367, PubMed:31452512). The DCX(DCAF15) complex acts as a regulator of the natural killer (NK) cells effector functions, possibly by mediating ubiquitination and degradation of cohesin subunits SMC1A and SMC3 (PubMed:31452512). May play a role in the activation of antigen-presenting cells (APC) and their interaction with NK cells (PubMed:31452512)

The "DCAF15 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about DCAF15 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets