ORC3: A Protein Involved in Immune Response and Potential Drug Target

Target Name: ORC3

NCBI ID: G23595

ORC3

ORC3: A Protein Involved in Immune Response and Potential Drug Target

ORC3, Origin Recognition Complex subunit 3 (isoform 1), is a protein that plays a crucial role in the process of origin recognition in the immune system. ORC3 is a subunit of the ORC3 complex, which is responsible for recognizing the origin of foreign particles. in the body, such as viruses and bacteria. ORC3 is a well-known protein that has been studied extensively in the field of immunology, and it has potential as a drug target or biomarker.

ORC3 was first identified in the 1990s as a protein that was expressed in the human body and was involved in the process of antigen presentation. Subsequently, ORC3 was shown to be involved in the recognition of intracellular foreign particles, such as viruses and bacteria. ORC3 is a member of the superfamily of leucine-rich repeats (LRR), which are a common structural motif in proteins that are involved in cell signaling and are characterized by the presence of a leucine-rich repeat in the protein sequence.

ORC3 is a 21-kDa protein that consists of 255 amino acid residues. It has a characteristic linear molecular structure and a calculated molecular mass of 34.1 kDa. ORC3 is predominantly expressed in the cytoplasm of human cells and is also found in the endoplasmic reticulum ( ER) and the nuclear envelope (NE). ORC3 is involved in the recognition of intracellular foreign particles, which require it to form a complex with several other proteins, including the transmembrane protein T-cell antigen 4 (TCA4) and the cytoplasmic protein MHC class I molecules.

ORC3 plays a crucial role in the process of origin recognition in the immune system. When a foreign particle is introduced into the body, ORC3 is the first protein to recognize it and initiate an immune response. ORC3 recognizes the foreign particle by its cell surface antigens , which are specific determinants that are present on the surface of the foreign particle. Once ORC3 has recognized the foreign particle, it forms a complex with TCA4 and MHC class I molecules, which help to load the foreign particle onto the MHC class I molecules and present it to T cells for destruction.

ORC3 is also involved in the regulation of the immune response. ORC3 has also been shown to play a role in the regulation of T cell responses, including the regulation of T cell proliferation, differentiation, and selection. in the regulation of antibody production, including the regulation of the humoral response to foreign particles.

ORC3 is a potential drug target or biomarker because of its involvement in the immune response and its well-documented structure. Studies have shown that inhibiting ORC3 activity can enhance the immune response against viruses and bacteria, which could have implications for the development of vaccines and bacteria treatments for infectious diseases. Additionally, ORC3 has been shown to be involved in the regulation of the immune response, which could provide insight into the mechanisms underlying autoimmune diseases.

In conclusion, ORC3 is a well-known protein that plays a crucial role in the process of origin recognition in the immune system. ORC3 is a member of the superfamily of LRR and has been shown to be involved in the regulation of the immune response. As a result, ORC3 is a potential drug target or biomarker, and its study may provide insight into the mechanisms underlying autoimmune diseases and other immune-related conditions. Further research is needed to fully understand the role of ORC3 in the immune response and its potential as a drug target or biomarker.

Protein Name: Origin Recognition Complex Subunit 3

Functions: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3

The "ORC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ORC3 comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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